Open Loop Optogenetic Control of Simulated Cortical Epileptiform Activity

Overview

Journal J Comput Neurosci

Specialties Biology
Neurology

Date 2013 Nov 1

PMID 24174320

Citations 8

Authors

Prashanth Selvaraj

Jamie W Sleigh

Walter J Freeman

Heidi E Kirsch

Andrew J Szeri

Affiliations

Soon will be listed here.

Abstract

We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage.

Citing Articles

Dynamical Mechanism Analysis of Three Neuroregulatory Strategies on the Modulation of Seizures.

Zhang H, Shen Z, Zhao Y, Du L, Deng Z Int J Mol Sci. 2022; 23(21).

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Suppression of epileptic seizures via Anderson localization.

Zhang B, Chamanzar M, Alam M J R Soc Interface. 2017; 14(127).

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Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.

Bui A, Alexander A, Soltesz I Neuroscientist. 2015; 23(1):68-81.

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Optimal control based seizure abatement using patient derived connectivity.

Taylor P, Thomas J, Sinha N, Dauwels J, Kaiser M, Thesen T Front Neurosci. 2015; 9:202.

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Future of seizure prediction and intervention: closing the loop.

Nagaraj V, Lee S, Krook-Magnuson E, Soltesz I, Benquet P, Irazoqui P J Clin Neurophysiol. 2015; 32(3):194-206.

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