Embryonic Stem Cells Shed New Light on the Developmental Roles of P53

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2013 Nov 1

PMID 24171803

Citations 6

Authors

Min Hwa Shin

Yunlong He

Jing Huang

Affiliations

Soon will be listed here.

Abstract

The viability and subtle developmental defects of p53 knockout mice suggest that p53 does not play major role in development. However, contradictory evidence also exists. This discrepancy mainly results from the lack of molecular and cellular mechanisms and the general fact that p53 activation requires stresses. Recent studies of p53 in mouse and human ES cells and induced pluripotent stem (iPS) cells shed new light on the mechanisms of the developmental roles of p53. This review summarizes these new studies that support the developmental roles of p53, highlights the possible underlying molecular mechanisms, and discusses the potential relationship between the developmental roles and the tumor suppressive function of p53. In summary, the molecular mechanisms underlying the developmental roles of p53 are emerging, and the developmental roles and tumor suppressive function of p53 may be closely related.

Citing Articles

An Updated View of the Roles of p53 in Embryonic Stem Cells.

Ayaz G, Yan H, Malik N, Huang J Stem Cells. 2022; 40(10):883-891.

PMID: 35904997 PMC: 9585900. DOI: 10.1093/stmcls/sxac051.

Developmental Acquisition of Functions.

Jaiswal S, Raj S, DePamphilis M Genes (Basel). 2021; 12(11).

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The Mutant Mice: A Ciliopathy Model That Uncouples Ciliogenesis From Planar Cell Polarity.

Marques M, Villoch-Fernandez J, Maeso-Alonso L, Fuertes-Alvarez S, Marin M Front Genet. 2019; 10:154.

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p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity.

Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K Genes Dev. 2017; 31(10):959-972.

PMID: 28607180 PMC: 5495125. DOI: 10.1101/gad.299198.117.

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

Page A, Navarro M, Suarez-Cabrera C, Alameda J, Casanova M, Paramio J Oncotarget. 2016; 7(15):20902-18.

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