Metal-free [3 + 2 + 1]/[2 + 2 + 1] Biscyclization: Stereospecific Construction with Concomitant Functionalization of Indolizin-5(1H)-one

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Oct 31

PMID 24168348

Authors

Tuan-Jie Li

Zhong-Qiu Liu

Hong-Mei Yin

Chang-Sheng Yao

Bo Jiang

Xiang-Shan Wang

Shu-Jiang Tu

Xiu-Ling Li

Guigen Li

Affiliations

Soon will be listed here.

Abstract

A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new σ bonds and six stereocenters including a quaternary carbon center in a single operation.

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