DHAP-dependent Aldolases from (hyper)thermophiles: Biochemistry and Applications

Overview

Journal Extremophiles

Publisher Springer

Date 2013 Oct 30

PMID 24166576

Citations 6

Authors

Pierpaolo Falcicchio

Suzanne Wolterink-van Loo

Maurice C R Franssen

John van der Oost

Affiliations

Soon will be listed here.

Abstract

Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed.

Citing Articles

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Multidisciplinary involvement and potential of thermophiles.

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