Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma Within 10 Years

Overview

Journal Case Rep Oncol

Publisher Karger

Specialty Oncology

Date 2013 Oct 29

PMID 24163664

Citations 14

Authors

Yasuhito Tanase

Naoto Furukawa

Hiroshi Kobayashi

Takashi Matsumoto

Affiliations

Soon will be listed here.

Abstract

Atypical endometriosis is reported to possess a precancerous potential attributed to premalignant changes characterized by cytological atypia and architecture proliferation. Moreover, the coexistence of atypical endometriosis and neoplasms had been reported. However, cases of atypical endometriosis transformation to carcinoma are rarely reported. We describe the case of a 33-year-old woman who had a long therapeutic history of endometriosis. Three laparoscopic surgeries were performed to treat endometriosis. After the third surgery, she was diagnosed as having grade 1 endometrioid adenocarcinoma. The histological review of the previous surgery confirmed the diagnosis of atypical endometriosis based on the second specimen. The patient's disease progressed from a benign endometriotic cyst to atypical endometriosis and finally to endometrioid adenocarcinoma within 10 years. When we encounter cases of atypical endometriosis, it is necessary to consider the possibility of ovarian cancer and carefully follow the patients for long periods.

Citing Articles

Genetic Links between Endometriosis and Endometriosis-Associated Ovarian Cancer-A Narrative Review (Endometriosis-Associated Cancer).

Pejovic T, Cathcart A, Alwaqfi R, Brooks M, Kelsall R, Nezhat F Life (Basel). 2024; 14(6).

PMID: 38929687 PMC: 11204815. DOI: 10.3390/life14060704.

Endometriosis-Related Ovarian Cancer: Where Are We Now? A Narrative Review towards a Pragmatic Approach.

Centini G, Schettini G, Pieri E, Giorgi M, Lazzeri L, Martire F J Clin Med. 2024; 13(7).

PMID: 38610698 PMC: 11012952. DOI: 10.3390/jcm13071933.

The many faces of endometriosis.

de Souza M, da Costa T, de Freitas N, de Souza M, Athanazio D Autops Case Rep. 2022; 12:e2021409.

PMID: 36381229 PMC: 9639587. DOI: 10.4322/acr.2021.409.

Endometrial cancer with concomitant endometriosis is highly associated with ovarian endometrioid carcinoma: a retrospective cohort study.

Ishizaka A, Taguchi A, Tsuruga T, Maruyama M, Kawata A, Miyamoto Y BMC Womens Health. 2022; 22(1):332.

PMID: 35932070 PMC: 9354371. DOI: 10.1186/s12905-022-01917-5.

Predictive factors of endometriosis progression into ovarian cancer.

Varga J, Reviczka A, Hakova H, Svajdler P, Rabajdova M, Ostro A J Ovarian Res. 2022; 15(1):5.

PMID: 35012617 PMC: 8751310. DOI: 10.1186/s13048-021-00940-8.

References

Bayramoglu H, Duzcan E . Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis. Pathol Oncol Res. 2001; 7(1):33-8. DOI: 10.1007/BF03032602. View

Hyman M . Extraovarian endometrioid carcinoma. Review of the literature and report of two cases with unusual features. Am J Clin Pathol. 1977; 68(4):522-7. DOI: 10.1093/ajcp/68.4.522. View

Oral E, Ilvan S, Tustas E, Korbeyli B, Bese T, Demirkiran F . Prevalence of endometriosis in malignant epithelial ovary tumours. Eur J Obstet Gynecol Reprod Biol. 2003; 109(1):97-101. DOI: 10.1016/s0301-2115(03)00047-2. View

Vercellini P, Scarfone G, Bolis G, Stellato G, Carinelli S, Crosignani P . Site of origin of epithelial ovarian cancer: the endometriosis connection. BJOG. 2000; 107(9):1155-7. DOI: 10.1111/j.1471-0528.2000.tb11116.x. View

Modesitt S, Tortolero-Luna G, Robinson J, Gershenson D, Wolf J . Ovarian and extraovarian endometriosis-associated cancer. Obstet Gynecol. 2002; 100(4):788-95. DOI: 10.1016/s0029-7844(02)02149-x. View

Moll U, Chumas J, Chalas E, Mann W . Ovarian carcinoma arising in atypical endometriosis. Obstet Gynecol. 1990; 75(3 Pt 2):537-9. View

LaGrenade A, Silverberg S . Ovarian tumors associated with atypical endometriosis. Hum Pathol. 1988; 19(9):1080-4. DOI: 10.1016/s0046-8177(88)80090-x. View

Ogawa S, Kaku T, Amada S, Kobayashi H, Hirakawa T, Ariyoshi K . Ovarian endometriosis associated with ovarian carcinoma: a clinicopathological and immunohistochemical study. Gynecol Oncol. 2000; 77(2):298-304. DOI: 10.1006/gyno.2000.5765. View

Fukunaga M, Nomura K, Ishikawa E, Ushigome S . Ovarian atypical endometriosis: its close association with malignant epithelial tumours. Histopathology. 1997; 30(3):249-55. DOI: 10.1046/j.1365-2559.1997.d01-592.x. View

10.

Tagashira Y, Shimada M, Kigawa J, Iba T, Terakawa N . Ovarian endometrioid adenocarcinoma arising from endometriosis in a young woman. Gynecol Oncol. 2003; 91(3):643-7. DOI: 10.1016/j.ygyno.2003.08.005. View

11.

Seidman J . Prognostic importance of hyperplasia and atypia in endometriosis. Int J Gynecol Pathol. 1996; 15(1):1-9. DOI: 10.1097/00004347-199601000-00001. View

12.

Steed H, Chapman W, Laframboise S . Endometriosis-associated ovarian cancer: a clinicopathologic review. J Obstet Gynaecol Can. 2004; 26(8):709-15. DOI: 10.1016/s1701-2163(16)30642-9. View

13.

Czernobilsky B, Morris W . A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. Obstet Gynecol. 1979; 53(3):318-23. View

14.

Scott R . Malignant changes in endometriosis. Obstet Gynecol. 1953; 2(3):283-9. View