» Articles » PMID: 24162027

Past, Present and Future: 30 Years of HIV Research

Overview
Date 2013 Oct 29
PMID 24162027
Citations 106
Authors
Affiliations
Soon will be listed here.
Abstract

This year marks the thirtieth anniversary of the publication of the study that first reported the isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the major milestones in HIV science, highlighting how translational research has affected treatment and prevention of HIV. Finally, we discuss some of the current research directions and the scientific challenges ahead, in particular in the search for a cure for HIV.

Citing Articles

Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells.

Schlosser V, Lightfoot H, Leemann C, Bejoy A, Tiwari S, Schlosshauer J Noncoding RNA. 2025; 11(1.

PMID: 39846686 PMC: 11755467. DOI: 10.3390/ncrna11010008.


Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size.

Aouizerat B, Garcia J, Domingues C, Xu K, Quach B, Page G J Acquir Immune Defic Syndr. 2024; 97(2):156-164.

PMID: 39250649 PMC: 11752676. DOI: 10.1097/QAI.0000000000003472.


In Vitro Anti-HIV-1 Activity of Fucoidans from Brown Algae.

Nosik M, Krylova N, Usoltseva R, Surits V, Kireev D, Shchelkanov M Mar Drugs. 2024; 22(8).

PMID: 39195471 PMC: 11355542. DOI: 10.3390/md22080355.


CRISPR-Cpf1 system and its applications in animal genome editing.

Han Y, Jia Z, Xu K, Li Y, Lu S, Guan L Mol Genet Genomics. 2024; 299(1):75.

PMID: 39085660 DOI: 10.1007/s00438-024-02166-x.


Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments.

Hinton Jr A, Njai A, Vue Z, Wanjalla C Circ Res. 2024; 134(11):1581-1606.

PMID: 38781302 PMC: 11122810. DOI: 10.1161/CIRCRESAHA.124.324296.


References
1.
Weiss R . Thirty years on: HIV receptor gymnastics and the prevention of infection. BMC Biol. 2013; 11:57. PMC: 3660199. DOI: 10.1186/1741-7007-11-57. View

2.
Buchbinder S, Mehrotra D, Duerr A, Fitzgerald D, Mogg R, Li D . Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008; 372(9653):1881-1893. PMC: 2721012. DOI: 10.1016/S0140-6736(08)61591-3. View

3.
Walker L, Huber M, Doores K, Falkowska E, Pejchal R, Julien J . Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011; 477(7365):466-70. PMC: 3393110. DOI: 10.1038/nature10373. View

4.
Maddon P, Dalgleish A, McDougal J, Clapham P, Weiss R, Axel R . The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 1986; 47(3):333-48. DOI: 10.1016/0092-8674(86)90590-8. View

5.
Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S . Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12(12):1365-71. DOI: 10.1038/nm1511. View