Incubation Period of Ebola Hemorrhagic Virus Subtype Zaire

Overview

Journal Osong Public Health Res Perspect

Specialty Public Health

Date 2013 Oct 26

PMID 24159443

Citations 35

Authors

Martin Eichner

Scott F Dowell

Nina Firese

Affiliations

Soon will be listed here.

Abstract

Objectives: Ebola hemorrhagic fever has killed over 1300 people, mostly in equatorial Africa. There is still uncertainty about the natural reservoir of the virus and about some of the factors involved in disease transmission. Until now, a maximum incubation period of 21 days has been assumed.

Methods: We analyzed data collected during the Ebola outbreak (subtype Zaire) in Kikwit, Democratic Republic of the Congo, in 1995 using maximum likelihood inference and assuming a log-normally distributed incubation period.

Results: The mean incubation period was estimated to be 12.7 days (standard deviation 4.31 days), indicating that about 4.1% of patients may have incubation periods longer than 21 days.

Conclusion: If the risk of new cases is to be reduced to 1% then 25 days should be used when investigating the source of an outbreak, when determining the duration of surveillance for contacts, and when declaring the end of an outbreak.

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References

Hayman D, Emmerich P, Yu M, Wang L, Suu-Ire R, Fooks A . Long-term survival of an urban fruit bat seropositive for Ebola and Lagos bat viruses. PLoS One. 2010; 5(8):e11978. PMC: 2915915. DOI: 10.1371/journal.pone.0011978. View

Chowell G, Hengartner N, Castillo-Chavez C, Fenimore P, Hyman J . The basic reproductive number of Ebola and the effects of public health measures: the cases of Congo and Uganda. J Theor Biol. 2004; 229(1):119-26. DOI: 10.1016/j.jtbi.2004.03.006. View

Okware S, Omaswa F, Zaramba S, Opio A, Lutwama J, Kamugisha J . An outbreak of Ebola in Uganda. Trop Med Int Health. 2002; 7(12):1068-75. DOI: 10.1046/j.1365-3156.2002.00944.x. View

Leroy E, Rouquet P, Formenty P, Souquiere S, Kilbourne A, Froment J . Multiple Ebola virus transmission events and rapid decline of central African wildlife. Science. 2004; 303(5656):387-90. DOI: 10.1126/science.1092528. View

Horowitz M, Cohen N, Takai S, Becu T, Chaffin M, Chu K . Application of Sartwell's model (lognormal distribution of incubation periods) to age at onset and age at death of foals with Rhodococcus equi pneumonia as evidence of perinatal infection. J Vet Intern Med. 2001; 15(3):171-5. DOI: 10.1892/0891-6640(2001)015<0171:aosmld>2.3.co;2. View

Feldmann H, Wahl-Jensen V, Jones S, Stroher U . Ebola virus ecology: a continuing mystery. Trends Microbiol. 2004; 12(10):433-7. DOI: 10.1016/j.tim.2004.08.009. View

Biek R, Walsh P, Leroy E, Real L . Recent common ancestry of Ebola Zaire virus found in a bat reservoir. PLoS Pathog. 2006; 2(10):e90. PMC: 1626099. DOI: 10.1371/journal.ppat.0020090. View

Baron R, McCormick J, Zubeir O . Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bull World Health Organ. 1983; 61(6):997-1003. PMC: 2536233. View

Muyembe-Tamfum J, Kipasa M, Kiyungu C, Colebunders R . Ebola outbreak in Kikwit, Democratic Republic of the Congo: discovery and control measures. J Infect Dis. 1999; 179 Suppl 1:S259-62. DOI: 10.1086/514302. View

10.

Normile D . Emerging infectious diseases. Scientists puzzle over Ebola-Reston virus in pigs. Science. 2009; 323(5913):451. DOI: 10.1126/science.323.5913.451a. View

11.

Crowcroft N, Morgan D, Brown D . Viral haemorrhagic fevers in Europe--effective control requires a co-ordinated response. Euro Surveill. 2003; 7(3):31-2. DOI: 10.2807/esm.07.03.00343-en. View

12.

Lloyd E, Zaki S, Rollin P, Tshioko K, Bwaka M, Ksiazek T . Long-term disease surveillance in Bandundu region, Democratic Republic of the Congo: a model for early detection and prevention of Ebola hemorrhagic fever. J Infect Dis. 1999; 179 Suppl 1:S274-80. DOI: 10.1086/514312. View

13.

Wolfe N, Prosser T, Carr J, Tamoufe U, Mpoudi-Ngole E, Torimiro J . Exposure to nonhuman primates in rural Cameroon. Emerg Infect Dis. 2005; 10(12):2094-9. PMC: 3323379. DOI: 10.3201/eid1012.040062. View

14.

Francesconi P, Yoti Z, Declich S, Onek P, Fabiani M, Olango J . Ebola hemorrhagic fever transmission and risk factors of contacts, Uganda. Emerg Infect Dis. 2004; 9(11):1430-7. PMC: 3035551. DOI: 10.3201/eid0911.030339. View

15.

Dowell S, Mukunu R, Ksiazek T, Khan A, Rollin P, Peters C . Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidémies à Kikwit. J Infect Dis. 1999; 179 Suppl 1:S87-91. DOI: 10.1086/514284. View

16.

Guimard Y, Bwaka M, Colebunders R, Calain P, Massamba M, de Roo A . Organization of patient care during the Ebola hemorrhagic fever epidemic in Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis. 1999; 179 Suppl 1:S268-73. DOI: 10.1086/514315. View

17.

Sadek R, Khan A, Stevens G, Peters C, Ksiazek T . Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival. J Infect Dis. 1999; 179 Suppl 1:S24-7. DOI: 10.1086/514311. View

18.

Towner J, Sealy T, Khristova M, Albarino C, Conlan S, Reeder S . Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathog. 2008; 4(11):e1000212. PMC: 2581435. DOI: 10.1371/journal.ppat.1000212. View

19.

Bwaka M, Bonnet M, Calain P, Colebunders R, de Roo A, Guimard Y . Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J Infect Dis. 1999; 179 Suppl 1:S1-7. DOI: 10.1086/514308. View

20.

Chlibek R, Smetana J, Vackova M . [Ebola and Marburg fever--outbreaks of viral haemorrhagic fever]. Klin Mikrobiol Infekc Lek. 2007; 12(6):217-23. View