Polymorphic Variant at the IL2 Region is Associated with Type 1 Diabetes and May Affect Serum Levels of Interleukin-2

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2013 Oct 25

PMID 24154763

Citations 9

Authors

Marta Fichna

Magdalena Zurawek

Piotr Fichna

Iwona Ziolkowska-Suchanek

Danuta Januszkiewicz

Jerzy Nowak

Affiliations

Soon will be listed here.

Abstract

Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune disorders. Our aim was to evaluate the association of the four IL2 polymorphisms (rs6822844, rs6534349, rs2069762 and rs3136534) with type 1 diabetes (T1D) in the Polish population, and to correlate them with the serum interleukin-2 levels. 543 unrelated T1D patients and 706 healthy control subjects were enrolled. The minor T allele at rs6822844 was significantly less frequent in T1D compared to controls (p = 0.002; OR 0.71; 95 % CI 0.571-0.880). Likewise, the frequency of the TT genotype was decreased among the affected individuals (p = 0.007). In healthy subjects, stratification according to the rs6822844 genotype revealed significant differences in circulating interleukin-2 (p = 0.037) with the highest levels in TT protective genotypes. Three other IL2 polymorphisms did not display significant differences in allele and genotype distribution. In conclusion, the rs6822844 variant is associated with T1D and may play a functional role, or reflect the influence of another causative genetic variant in linkage disequilibrium.

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