P53/p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2013 Oct 24

PMID 24151513

Citations 30

Authors

Zhifeng Gu

Jinxia Jiang

Wei Tan

Yunfei Xia

Haixia Cao

Yan Meng

Zhanyun Da

Hong Liu

Chun Cheng

Affiliations

Soon will be listed here.

Abstract

Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. Numerous studies have shown that activation of the p53/p21 pathway inhibits the proliferation of BM-MSCs. The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms. We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence. The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients. Our results demonstrated that p53/p21 pathway played an important role in the senescence process of BM-MSCs from SLE.

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