Role of Adipokines Signaling in the Modulation of T Cells Function

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Oct 24

PMID 24151494

Citations 47

Authors

Claudio Procaccini

Veronica De Rosa

Mario Galgani

Fortunata Carbone

Claudia La Rocca

Luigi Formisano

Giuseppe Matarese

Affiliations

Soon will be listed here.

Abstract

The field that links immunity and metabolism is rapidly expanding. Apparently non-immunological disorders such as obesity and type 2 diabetes have been linked to immune dysregulation, suggesting that metabolic alterations can be induced by or be consequence of an altered self-immune tolerance. In this context, adipose tissue produces and releases a variety of pro-inflammatory and anti-inflammatory factors, termed "adipokines," which can be considered as the bridge between obesity-related exogenous factors, such as nutrition and lifestyle, and the molecular events leading to metabolic syndrome, inflammatory, and/or autoimmune conditions. In obesity, increased production of most adipokines impacts on multiple functions such as appetite and energy balance, modulation of immune responses, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism, and so on. This report aims to discuss some of the recent topics of adipocytokine research and their related signaling pathways, that may be of particular importance as could lead to effective therapeutic strategies for obesity-associated diseases.

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