A New Enantioselective Synthesis of the Anticonvulsant Drug Pregabalin (Lyrica) Based on a Hydrolytic Kinetic Resolution Method

Overview

Journal Chirality

Publisher Wiley

Date 2013 Oct 24

PMID 24151098

Citations 4

Authors

Mohammad Mujahid

Murugan Muthukrishnan

Affiliations

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Abstract

A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality.

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