Diagnosis and Phylogenetic Analysis of Ovine Pulmonary Adenocarcinoma in China

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2013 Oct 24

PMID 24150961

Citations 10

Authors

Keshan Zhang

Hanjin Kong

Yongjie Liu

Youjun Shang

Bin Wu

Xiangtao Liu

Affiliations

Soon will be listed here.

Abstract

Ovine pulmonary adenocarcinoma (OPA) is a lung tumor of sheep caused by jaagsiekte sheep retrovirus (JSRV). OPA is common in sheep, and it is most commonly observed in China. Without preventative vaccines and serological diagnostic tools for assay of OPA, identification of JSRV based on reverse transcription polymerase chain reaction (RT-PCR) is very important for prevention and control measures for OPA in practice management. In this study, the diagnosis of OPA was made from analysis of clinical signs, pathological observations, JSRV-like particle discovery, and RT-PCR of the target env gene. The phylogenetic analysis showed that the China Shandong (SD) strain studied in this article belonged to exogenous JSRV, and it was very similar to 92k3, which was isolated from sheep in the Kenya (Y18305). The current study reported a severe outbreak of OPA in Shandong Province, China. The observations could offer a comparative view of the env gene of JSRV.

Citing Articles

Lesion Localization and Pathological Diagnosis of Ovine Pulmonary Adenocarcinoma Based on MASK R-CNN.

Chen S, Zhang P, Duan X, Bao A, Wang B, Zhang Y Animals (Basel). 2024; 14(17).

PMID: 39272273 PMC: 11393988. DOI: 10.3390/ani14172488.

Identification of concurrent infection with Jaagsiekte sheep retrovirus and maedi-visna virus in China.

Duan X, Shi X, Zhang P, Du X, Chen S, Zhang L J Vet Sci. 2024; 25(5):e61.

PMID: 39231786 PMC: 11450398. DOI: 10.4142/jvs.24158.

Differences in CpG island distribution between exogenous and endogenous jaagsiekte sheep retrovirus strains.

Liu Q, Yu Y, Wang H Vet Res Forum. 2023; 14(10):531-539.

PMID: 37901353 PMC: 10612397. DOI: 10.30466/vrf.2022.552748.3454.

A Combined Approach for Detection of Ovine Small Ruminant Retrovirus Co-Infections.

Rosato G, Abril C, Hilbe M, Seehusen F Viruses. 2023; 15(2).

PMID: 36851589 PMC: 9958757. DOI: 10.3390/v15020376.

A novel strategy for developing vaccine candidate against Jaagsiekte sheep retrovirus from the envelope and gag proteins: an in-silico approach.

Mahmoud N, Elshafei A, Almofti Y BMC Vet Res. 2022; 18(1):343.

PMID: 36085036 PMC: 9463060. DOI: 10.1186/s12917-022-03431-0.

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