Stem Cell Therapies for the Treatment of Radiation-induced Normal Tissue Side Effects

Overview

Journal Antioxid Redox Signal

Specialty Endocrinology

Date 2013 Oct 24

PMID 24147585

Citations 49

Authors

Marc Benderitter

Fabio Caviggioli

Alain Chapel

Robert P Coppes

Chandan Guha

Marco Klinger

Olivier Malard

Fiona Stewart

Radia Tamarat

Peter van Luijk

Charles L Limoli

Affiliations

Soon will be listed here.

Abstract

Significance: Targeted irradiation is an effective cancer therapy but damage inflicted to normal tissues surrounding the tumor may cause severe complications. While certain pharmacologic strategies can temper the adverse effects of irradiation, stem cell therapies provide unique opportunities for restoring functionality to the irradiated tissue bed.

Recent Advances: Preclinical studies presented in this review provide encouraging proof of concept regarding the therapeutic potential of stem cells for treating the adverse side effects associated with radiotherapy in different organs. Early-stage clinical data for radiation-induced lung, bone, and skin complications are promising and highlight the importance of selecting the appropriate stem cell type to stimulate tissue regeneration.

Critical Issues: While therapeutic efficacy has been demonstrated in a variety of animal models and human trials, a range of additional concerns regarding stem cell transplantation for ameliorating radiation-induced normal tissue sequelae remain. Safety issues regarding teratoma formation, disease progression, and genomic stability along with technical issues impacting disease targeting, immunorejection, and clinical scale-up are factors bearing on the eventual translation of stem cell therapies into routine clinical practice.

Future Directions: Follow-up studies will need to identify the best possible stem cell types for the treatment of early and late radiation-induced normal tissue injury. Additional work should seek to optimize cellular dosing regimes, identify the best routes of administration, elucidate optimal transplantation windows for introducing cells into more receptive host tissues, and improve immune tolerance for longer-term engrafted cell survival into the irradiated microenvironment.

Citing Articles

Navigating the Complexities of Radiation Injuries: Therapeutic Principles and Reconstructive Strategies.

Grosu-Bularda A, Lita F, Hodea F, Bordeanu-Diaconescu E, Cretu A, Dumitru C J Pers Med. 2024; 14(11).

PMID: 39590592 PMC: 11595796. DOI: 10.3390/jpm14111100.

A bibliometric analysis of radiation-induced brain injury: a research of the literature from 1998 to 2023.

Lan J, Ren Y, Liu Y, Chen L, Liu J Discov Oncol. 2024; 15(1):364.

PMID: 39172266 PMC: 11341524. DOI: 10.1007/s12672-024-01223-6.

Wharton's jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury.

Sharma P, Maurya D World J Stem Cells. 2024; 16(7):742-759.

PMID: 39086560 PMC: 11287430. DOI: 10.4252/wjsc.v16.i7.742.

Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage.

Gupta K, Perkerson 3rd R, Parsons T, Angom R, Amerna D, Burgess J Stem Cell Res Ther. 2024; 15(1):230.

PMID: 39075600 PMC: 11287895. DOI: 10.1186/s13287-024-03847-5.

Cell Therapies for Acute Radiation Syndrome.

Christy B, Herzig M, Wu X, Mohammadipoor A, McDaniel J, Bynum J Int J Mol Sci. 2024; 25(13).

PMID: 39000080 PMC: 11241804. DOI: 10.3390/ijms25136973.

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