» Articles » PMID: 24146746

How Safe is Safe Enough? Radiation Risk for a Human Mission to Mars

Overview
Journal PLoS One
Date 2013 Oct 23
PMID 24146746
Citations 53
Authors
Affiliations
Soon will be listed here.
Abstract

Astronauts on a mission to Mars would be exposed for up to 3 years to galactic cosmic rays (GCR)--made up of high-energy protons and high charge (Z) and energy (E) (HZE) nuclei. GCR exposure rate increases about three times as spacecraft venture out of Earth orbit into deep space where protection of the Earth's magnetosphere and solid body are lost. NASA's radiation standard limits astronaut exposures to a 3% risk of exposure induced death (REID) at the upper 95% confidence interval (CI) of the risk estimate. Fatal cancer risk has been considered the dominant risk for GCR, however recent epidemiological analysis of radiation risks for circulatory diseases allow for predictions of REID for circulatory diseases to be included with cancer risk predictions for space missions. Using NASA's models of risks and uncertainties, we predicted that central estimates for radiation induced mortality and morbidity could exceed 5% and 10% with upper 95% CI near 10% and 20%, respectively for a Mars mission. Additional risks to the central nervous system (CNS) and qualitative differences in the biological effects of GCR compared to terrestrial radiation may significantly increase these estimates, and will require new knowledge to evaluate.

Citing Articles

Combined Effects of Microgravity and Chronic Low-Dose Gamma Radiation on Microgreens.

De Francesco S, Le Disquet I, Pereda-Loth V, Tisseyre L, De Pascale S, Amitrano C Plants (Basel). 2025; 14(1.

PMID: 39795322 PMC: 11722926. DOI: 10.3390/plants14010064.


Accelerated Aging Effects Observed In Vitro after an Exposure to Gamma-Rays Delivered at Very Low and Continuous Dose-Rate Equivalent to 1-5 Weeks in International Space Station.

Restier-Verlet J, Ferlazzo M, Granzotto A, Al-Choboq J, Bellemou C, Estavoyer M Cells. 2024; 13(20.

PMID: 39451221 PMC: 11506070. DOI: 10.3390/cells13201703.


Considering clonal hematopoiesis of indeterminate potential in space radiation risk analysis for hematologic cancers and cardiovascular disease.

Werneth C, Patel Z, Thompson M, Blattnig S, Huff J Commun Med (Lond). 2024; 4(1):105.

PMID: 38862635 PMC: 11166645. DOI: 10.1038/s43856-023-00408-4.


High-altitude balloon platform for studying the biological response of living organisms exposed to near-space environments.

Klomchitcharoen S, Wechakarn P, Tangwattanasirikun T, Smerwong N, Netrapathompornkij P, Chatmeeboon T Heliyon. 2024; 10(6):e27406.

PMID: 38496885 PMC: 10944226. DOI: 10.1016/j.heliyon.2024.e27406.


Human Health during Space Travel: State-of-the-Art Review.

Krittanawong C, Singh N, Scheuring R, Urquieta E, Bershad E, Macaulay T Cells. 2023; 12(1).

PMID: 36611835 PMC: 9818606. DOI: 10.3390/cells12010040.


References
1.
Goodhead D . Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol. 1994; 65(1):7-17. DOI: 10.1080/09553009414550021. View

2.
Badhwar G, Cucinotta F . A comparison of depth dependence of dose and linear energy transfer spectra in aluminum and polyethylene. Radiat Res. 2000; 153(1):1-8. DOI: 10.1667/0033-7587(2000)153[0001:acoddo]2.0.co;2. View

3.
Cherry J, Liu B, Frost J, Lemere C, Williams J, Olschowka J . Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2013; 7(12):e53275. PMC: 3534034. DOI: 10.1371/journal.pone.0053275. View

4.
Chylack Jr L, Feiveson A, Peterson L, Tung W, Wear M, Marak L . NASCA report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity. Radiat Res. 2012; 178(1):25-32. DOI: 10.1667/rr2876.1. View

5.
Britten R, Davis L, Johnson A, Keeney S, Siegel A, Sanford L . Low (20 cGy) doses of 1 GeV/u (56)Fe--particle radiation lead to a persistent reduction in the spatial learning ability of rats. Radiat Res. 2011; 177(2):146-51. DOI: 10.1667/rr2637.1. View