Ubiquitination-deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-induced Apoptosis

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2013 Oct 23

PMID 24144979

Citations 63

Authors

Mohammad Mahabub-Uz Zaman

Teruaki Nomura

Tsuyoshi Takagi

Tomoo Okamura

Wanzhu Jin

Toshie Shinagawa

Yasunori Tanaka

Shunsuke Ishii

Affiliations

Soon will be listed here.

Abstract

Tumor necrosis factor alpha (TNF-α) plays a role in apoptosis and proliferation in multiple types of cells, and defects in TNF-α-induced apoptosis are associated with various autoimmune diseases. Here, we show that TRIM27, a tripartite motif (TRIM) protein containing RING finger, B-box, and coiled-coil domains, positively regulates TNF-α-induced apoptosis. Trim27-deficient mice are resistant to TNF-α-d-galactosamine-induced hepatocyte apoptosis. Trim27-deficient mouse embryonic fibroblasts (MEFs) are also resistant to TNF-α-cycloheximide-induced apoptosis. TRIM27 forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which deubiquitinates receptor-interacting protein 1 (RIP1), resulting in the positive regulation of TNF-α-induced apoptosis. Our findings indicate that the ubiquitination-deubiquitination cascade mediated by the TRIM27-USP7 complex plays an important role in TNF-α-induced apoptosis.

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