Bioengineering in the Oral Cavity: Our Experience

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2013 Oct 22

PMID 24143092

Citations 4

Authors

L Catalfamo

E Belli

C Nava

E Mici

A Calvo

B DAlessandro

F S De Ponte

Affiliations

Soon will be listed here.

Abstract

Background: To date, there are no studies reported in the literature on the possible use of bovine collagen, oxidized regenerated cellulose, or synthetic hyaluronic acid medications in the oral cavity. The aim of this paper is to report the use of bovine collagen, oxidized regenerated cellulose, and synthetic hyaluronic acid medications to improve wound healing in the oral cavity by stimulating granulomatous tissue.

Methods: From 2007 to 2011, 80 patients (median age 67 years) suffering from oral mucosal lesions participated in this double-blind study. The patients were divided into two groups, each consisting of 40 patients. One group received conventional medications, while the other group of patients were treated with the advanced medications.

Results: Advanced medications allowed re-epithelialization of the wound margin in 2-20 days, whereas patients receiving conventional medication showed a median healing duration of 45 days.

Conclusion: The results of this study demonstrate that treating oral mucosal wounds with advanced medication has an advantage with regard to wound healing time, allowing patients to have a rapid, functional, and esthetic recovery.

Citing Articles

The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study.

Zhou X, Cai Y, Zhao J Clin Oral Investig. 2024; 28(5):244.

PMID: 38583113 PMC: 10999378. DOI: 10.1007/s00784-024-05648-9.

Use of oxidised regenerated cellulose/collagen dressings versus standard of care over multiple wound types: A systematic review and meta-analysis.

Chowdhry S, Nieves-Malloure Y, Camardo M, Robertson J, Keys J Int Wound J. 2021; 19(2):241-252.

PMID: 34114731 PMC: 8762558. DOI: 10.1111/iwj.13625.

A monolateral TMJ replacement under intraoral endoscopic assistance for jaw osteomielitis: a modified approach.

Belli E, Mici E, Mazzone N, Catalfamo L, Fini G, Liberatore G G Chir. 2015; 36(1):36-9.

PMID: 25827669 PMC: 4396666.

Hyaluronan and cardiac regeneration.

Bonafe F, Govoni M, Giordano E, Caldarera C, Guarnieri C, Muscari C J Biomed Sci. 2014; 21:100.

PMID: 25358954 PMC: 4226915. DOI: 10.1186/s12929-014-0100-4.

References

Veves A, Sheehan P, Pham H . A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002; 137(7):822-7. DOI: 10.1001/archsurg.137.7.822. View

Ghatnekar O, Willis M, Persson U . Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries. J Wound Care. 2002; 11(2):70-4. DOI: 10.12968/jowc.2002.11.2.26675. View

Barrick B, Campbell E, Owen C . Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes. Wound Repair Regen. 2000; 7(6):410-22. DOI: 10.1046/j.1524-475x.1999.00410.x. View

Ravanti L, Kahari V . Matrix metalloproteinases in wound repair (review). Int J Mol Med. 2000; 6(4):391-407. View

Chen W, Abatangelo G . Functions of hyaluronan in wound repair. Wound Repair Regen. 1999; 7(2):79-89. DOI: 10.1046/j.1524-475x.1999.00079.x. View

Nwomeh B, Yager D, Cohen I . Physiology of the chronic wound. Clin Plast Surg. 1998; 25(3):341-56. View

Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams D . Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials. 1999; 19(23):2101-27. DOI: 10.1016/s0142-9612(98)00042-8. View

Vin F, Teot L, Meaume S . The healing properties of Promogran in venous leg ulcers. J Wound Care. 2002; 11(9):335-41. DOI: 10.12968/jowc.2002.11.9.26438. View

Price R, Das-Gupta V, Leigh I, Navsaria H . A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model. Tissue Eng. 2007; 12(10):2985-95. DOI: 10.1089/ten.2006.12.2985. View

10.

West D, Hampson I, Arnold F, Kumar S . Angiogenesis induced by degradation products of hyaluronic acid. Science. 1985; 228(4705):1324-6. DOI: 10.1126/science.2408340. View

11.

Motta G, Ratto G, DE BARBIERI A, Corte G, Zardi L, Sacco A . Can heterologous collagen enhance the granulation tissue growth? An experimental study. Ital J Surg Sci. 1983; 13(2):101-8. View

12.

Derbyshire A . The use of combination treatments and dressings for a traumatic wound. Br J Nurs. 2004; 13(16):987-93. DOI: 10.12968/bjon.2004.13.16.15976. View

13.

Guarnera G, Restuccia A . Promogran and complex surgical lesions: a case report. J Wound Care. 2004; 13(6):237-9. DOI: 10.12968/jowc.2004.13.6.26628. View

14.

Cullen B, Smith R, McCulloch E, Silcock D, Morrison L . Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers. Wound Repair Regen. 2002; 10(1):16-25. DOI: 10.1046/j.1524-475x.2002.10703.x. View

15.

Vaheri A, Stephens R, Salonen E, Pollanen J, Tapiovaara H . Plasminogen activation at the cell surface-matrix interface. Cell Differ Dev. 1990; 32(3):255-62. DOI: 10.1016/0922-3371(90)90038-x. View

16.

Myers S, Partha V, Soranzo C, Price R, Navsaria H . Hyalomatrix: a temporary epidermal barrier, hyaluronan delivery, and neodermis induction system for keratinocyte stem cell therapy. Tissue Eng. 2007; 13(11):2733-41. DOI: 10.1089/ten.2007.0109. View