Rosiglitazone Attenuates the Severity of Hyperlipidemic Severe Acute Pancreatitis in Rats

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2013 Oct 19

PMID 24137303

Citations 5

Authors

Batur Niyaz

Kai-Liang Zhao

Li-Min Liu

Chen Chen

Wen-Hong Deng

Teng Zuo

Qiao Shi

Wei-Xing Wang

Affiliations

Soon will be listed here.

Abstract

Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti-inflammatory effects. However, the mechanisms by which PPAR-γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR-γ ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate-induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high-lipid diet-induced hyperlipidemia and SAP.

Citing Articles

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HIF-1α-PPARγ-mTORC1 signaling pathway-mediated autophagy induces inflammatory response in pancreatic cells in rats with hyperlipidemic acute pancreatitis.

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Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR-γ/NF-κB signaling pathway.

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Rosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitis.

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