Astrocyte Elevated Gene-1 is a Novel Biomarker of Epithelial-mesenchymal Transition and Progression of Hepatocellular Carcinoma in Two China Regions

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Oct 19

PMID 24136747

Citations 12

Authors

Jiasheng Zheng

Cong Li

Xia Wu

Yingzhuo Yang

Meijun Hao

Shoupeng Sheng

Yu Sun

Honghai Zhang

Jiang Long

Caixia Hu

Affiliations

Soon will be listed here.

Abstract

Astrocyte elevated gene-1 (AEG-1) is involved in important biological processes including cell invasion, metastasis, and carcinogenesis. However, its clinical significance has remained largely unknown in hepatocellular carcinoma. Here, specimens from 144 patients with hepatocellular carcinomas in Beijing and Heilongjiang regions were investigated by immunohistochemical staining for AEG-1, vimentin, and E-cadherin expressions. A clinicopathological study revealed that AEG-1 expression level in tumor cells was significantly correlated with TNM stage (P = 0.001) and Edmonson grade (P < 0.0001). In addition, AEG-1, vimentin, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that AEG-1 may be an epithelial-mesenchymal transition-associated biomarker in human hepatocellular carcinoma and play important roles in the progression of hepatocellular carcinoma. In addition, the AEG-1 gene is a potential target for elimination of hepatocellular carcinoma in the future.

Citing Articles

AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.

Wu S, Yang L, Wu D, Gao Z, Li P, Huang W J Cell Mol Med. 2017; 21(12):3481-3493.

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Metadherin regulates epithelial-mesenchymal transition in carcinoma.

Wang Z, Tang Z, Yin Z, Wei Y, Liu L, Yan B Onco Targets Ther. 2016; 9:2429-36.

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A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway.

Li C, Wu X, Zhang H, Yang G, Hao M, Sheng S Tumour Biol. 2015; 36(8):6285-93.

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Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.

Gan T, Tang R, He R, Dang Y, Xie Y, Chen G Int J Clin Exp Med. 2015; 8(1):714-21.

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Astrocyte elevated gene-1 overexpression in hepatocellular carcinoma: an independent prognostic factor.

Jung H, Ahn T, Bae S, Chung J, Kim H, Chin S Ann Surg Treat Res. 2015; 88(2):77-85.

PMID: 25692118 PMC: 4325651. DOI: 10.4174/astr.2015.88.2.77.

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