Volume Quantification by Contrast-enhanced Ultrasound: an In-vitro Comparison with True Volumes and Thermodilution

Overview

Journal Cardiovasc Ultrasound

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
Radiology

Date 2013 Oct 19

PMID 24134671

Citations 4

Authors

Ingeborg H F Herold

Gianna Russo

Massimo Mischi

Patrick Houthuizen

Tamerlan Saidov

Marcel van Het Veer

Hans C van Assen

Hendrikus H M Korsten

Affiliations

Soon will be listed here.

Abstract

Background: Contrast-enhanced ultrasound (CEUS) has recently been proposed as a minimally- invasive, alternative method for blood volume measurement. This study aims at comparing the accuracy of CEUS and the classical thermodilution techniques for volume assessment in an in-vitro set-up.

Methods: The in-vitro set-up consisted of a variable network between an inflow and outflow tube and a roller pump. The inflow and outflow tubes were insonified with an ultrasound array transducer and a thermistor was placed in each tube. Indicator dilution curves were made by injecting indicator which consisted of an ultrasound-contrast-agent diluted in ice-cold saline. Both acoustic intensity- and thermo-dilution curves were used to calculate the indicator mean transit time between the inflow and outflow tube. The volumes were derived by multiplying the estimated mean transit time by the flow rate. We compared the volumes measured by CEUS with the true volumes of the variable network and those measured by thermodilution by Bland-Altman and intraclass-correlation analysis.

Results: The measurements by CEUS and thermodilution showed a very strong correlation (rs = 0.94) with a modest volume underestimation by CEUS of -40 ± 28 mL and an overestimation of 84 ± 62 mL by thermodilution compared with the true volumes. Both CEUS and thermodilution showed a high statistically significant correlation with the true volume (rs = 0.97 (95% CI, 0.95 - 0.98; P<0.0001) and rs = 0.96 (95% CI, 0.94 - 0.98; P<0.0001, respectively).

Conclusions: CEUS volume estimation provides a strong correlation with both the true volumes in-vitro and volume estimation by thermodilution. It may therefore represent an interesting alternative to the standard, invasive thermodilution technique.

Citing Articles

Prognostic Value of Pulmonary Transit Time and Pulmonary Blood Volume Estimation Using Myocardial Perfusion CMR.

Seraphim A, Knott K, Menacho K, Augusto J, Davies R, Pierce I JACC Cardiovasc Imaging. 2021; 14(11):2107-2119.

PMID: 34023269 PMC: 8560640. DOI: 10.1016/j.jcmg.2021.03.029.

The relationship between pulmonary artery wedge pressure and pulmonary blood volume derived from contrast echocardiography: A proof-of-concept study.

Monahan K, Lenihan D, Brittain E, Saliba L, Piana R, Robison L Echocardiography. 2018; 35(9):1266-1270.

PMID: 29756230 PMC: 6168381. DOI: 10.1111/echo.14023.

Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony.

Herold I, Saporito S, Mischi M, van Assen H, Arthur Bouwman R, de Lepper A Echo Res Pract. 2016; 3(2):35-43.

PMID: 27249553 PMC: 4989099. DOI: 10.1530/ERP-16-0011.

Reliability, repeatability, and reproducibility of pulmonary transit time assessment by contrast enhanced echocardiography.

Herold I, Saporito S, Arthur Bouwman R, Houthuizen P, van Assen H, Mischi M Cardiovasc Ultrasound. 2016; 14:1.

PMID: 26729228 PMC: 4700640. DOI: 10.1186/s12947-015-0044-1.

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