The Role of Extracellular Vesicles in Phenotypic Cancer Transformation

Overview

Journal Radiol Oncol

Publisher Sciendo

Specialties Oncology
Radiology

Date 2013 Oct 18

PMID 24133383

Citations 42

Authors

Eva Ogorevc

Veronika Kralj-Iglic

Peter Veranic

Affiliations

Soon will be listed here.

Abstract

Background: Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids.

Conclusions: Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EV-mediated cancer phenotypic transformation in the light of possible therapeutic applications.

Citing Articles

Rapid isolation method for extracellular vesicles based on FeO@ZrO.

Ma C, Xu Z, Hao K, Fan L, Du W, Gao Z Front Bioeng Biotechnol. 2024; 12:1399689.

PMID: 39045537 PMC: 11263208. DOI: 10.3389/fbioe.2024.1399689.

MicroRNA Nano-Shuttles: Engineering Extracellular Vesicles as a Cutting-Edge Biotechnology Platform for Clinical Use in Therapeutics.

Menjivar N, Oropallo J, Gebremedhn S, Souza L, Gad A, Puttlitz C Biol Proced Online. 2024; 26(1):14.

PMID: 38773366 PMC: 11106895. DOI: 10.1186/s12575-024-00241-6.

Potential Protective Role of Melatonin in Benign Mammary Cells Reprogrammed by Extracellular Vesicles from Malignant Cells.

Procopio de Oliveira C, Frigieri B, Fukumasu H, de Almeida Chuffa L, Novais A, de Campos Zuccari D Biomedicines. 2023; 11(10).

PMID: 37893209 PMC: 10604164. DOI: 10.3390/biomedicines11102837.

miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear's vulnerability to noise trauma.

Fujita T, Seist R, Kao S, Soares V, Panano L, Khetani R Front Neurol. 2023; 14:1268359.

PMID: 37885485 PMC: 10598552. DOI: 10.3389/fneur.2023.1268359.

Pathological and Therapeutic Significance of Tumor-Derived Extracellular Vesicles in Cancer Cell Migration and Metastasis.

Liguori G, Kralj-Iglic V Cancers (Basel). 2023; 15(18).

PMID: 37760395 PMC: 10648223. DOI: 10.3390/cancers15184425.

References

Ikonen E . Roles of lipid rafts in membrane transport. Curr Opin Cell Biol. 2001; 13(4):470-7. DOI: 10.1016/s0955-0674(00)00238-6. View

Bannert N, Kurth R . Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci U S A. 2004; 101 Suppl 2:14572-9. PMC: 521986. DOI: 10.1073/pnas.0404838101. View

Pap E . The role of microvesicles in malignancies. Adv Exp Med Biol. 2011; 714:183-99. DOI: 10.1007/978-94-007-0782-5_10. View

Tsui N, Ng E, Lo Y . Molecular analysis of circulating RNA in plasma. Methods Mol Biol. 2006; 336:123-34. DOI: 10.1385/1-59745-074-X:123. View

Koga K, Matsumoto K, Akiyoshi T, Kubo M, Yamanaka N, Tasaki A . Purification, characterization and biological significance of tumor-derived exosomes. Anticancer Res. 2005; 25(6A):3703-7. View

Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008; 10(12):1470-6. PMC: 3423894. DOI: 10.1038/ncb1800. View

Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov A . Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature. 1999; 401(6749):133-41. DOI: 10.1038/43613. View

Urbanija J, Babnik B, Frank M, Tomsic N, Rozman B, Kralj-Iglic V . Attachment of beta 2-glycoprotein I to negatively charged liposomes may prevent the release of daughter vesicles from the parent membrane. Eur Biophys J. 2008; 37(7):1085-95. DOI: 10.1007/s00249-007-0252-1. View

Segura E, Nicco C, Lombard B, Veron P, Raposo G, Batteux F . ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood. 2005; 106(1):216-23. DOI: 10.1182/blood-2005-01-0220. View

10.

Andre F, Schartz N, Movassagh M, Flament C, Pautier P, Morice P . Malignant effusions and immunogenic tumour-derived exosomes. Lancet. 2002; 360(9329):295-305. DOI: 10.1016/S0140-6736(02)09552-1. View

11.

Kozlov M . Fission of biological membranes: interplay between dynamin and lipids. Traffic. 2001; 2(1):51-65. DOI: 10.1034/j.1600-0854.2001.020107.x. View

12.

Ambrozic A, cucnik S, Tomsic N, Urbanija J, Lokar M, Babnik B . Interaction of giant phospholipid vesicles containing cardiolipin and cholesterol with beta2-glycoprotein-I and anti-beta2-glycoprotein-I antibodies. Autoimmun Rev. 2006; 6(1):10-5. DOI: 10.1016/j.autrev.2006.03.001. View

13.

Cocucci E, Racchetti G, Meldolesi J . Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009; 19(2):43-51. DOI: 10.1016/j.tcb.2008.11.003. View

14.

Jansa R, Sustar V, Frank M, Susanj P, Bester J, Mancek-Keber M . Number of microvesicles in peripheral blood and ability of plasma to induce adhesion between phospholipid membranes in 19 patients with gastrointestinal diseases. Blood Cells Mol Dis. 2008; 41(1):124-32. DOI: 10.1016/j.bcmd.2008.01.009. View

15.

Al-Nedawi K, Meehan B, Rak J . Microvesicles: messengers and mediators of tumor progression. Cell Cycle. 2009; 8(13):2014-8. DOI: 10.4161/cc.8.13.8988. View

16.

Hong B, Cho J, Kim H, Choi E, Rho S, Kim J . Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. BMC Genomics. 2009; 10:556. PMC: 2788585. DOI: 10.1186/1471-2164-10-556. View

17.

Sullivan R, Saez F, Girouard J, Frenette G . Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cells Mol Dis. 2005; 35(1):1-10. DOI: 10.1016/j.bcmd.2005.03.005. View

18.

May S, Iglic A, Rescic J, Maset S, Bohinc K . Bridging like-charged macroions through long divalent rodlike ions. J Phys Chem B. 2008; 112(6):1685-92. DOI: 10.1021/jp073355e. View

19.

Wolf P . The nature and significance of platelet products in human plasma. Br J Haematol. 1967; 13(3):269-88. DOI: 10.1111/j.1365-2141.1967.tb08741.x. View

20.

Pap E, Pallinger E, Falus A . The role of membrane vesicles in tumorigenesis. Crit Rev Oncol Hematol. 2010; 79(3):213-23. DOI: 10.1016/j.critrevonc.2010.07.015. View