» Articles » PMID: 24132110

The Roles of TGFβ in the Tumour Microenvironment

Overview
Journal Nat Rev Cancer
Specialty Oncology
Date 2013 Oct 18
PMID 24132110
Citations 517
Authors
Affiliations
Soon will be listed here.
Abstract

The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.

Citing Articles

Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing.

Miao K, Zhang A, Yang X, Zhang Y, Lin A, Wang L Mol Cancer. 2025; 24(1):75.

PMID: 40075470 PMC: 11899007. DOI: 10.1186/s12943-025-02279-w.


Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4 T cell differentiation.

Revilla S, Frederiks C, Prekovic S, Mocholi E, Kranenburg O, Coffer P iScience. 2025; 28(2):111827.

PMID: 39995881 PMC: 11848486. DOI: 10.1016/j.isci.2025.111827.


Cell Homing Strategies in Regenerative Endodontic Therapy.

Kim D, Kim S Cells. 2025; 14(3).

PMID: 39936992 PMC: 11817319. DOI: 10.3390/cells14030201.


Plasma membrane-coated nanoparticles and membrane vesicles to orchestrate multimodal antitumor immunity.

Ito Y, Kasuya H, Kataoka M, Nakamura N, Yoshikawa T, Nakashima T J Immunother Cancer. 2025; 13(1).

PMID: 39864848 PMC: 11784344. DOI: 10.1136/jitc-2024-010005.


Curcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy.

Alkhathami A, Alshahrani M, Alshehri S, Nasir N, Wahab S Sci Rep. 2025; 15(1):2871.

PMID: 39843618 PMC: 11754452. DOI: 10.1038/s41598-025-86289-0.


References
1.
Glenisson W, Castronovo V, Waltregny D . Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta. 2007; 1773(10):1572-82. DOI: 10.1016/j.bbamcr.2007.05.016. View

2.
Rifkin D . Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability. J Biol Chem. 2004; 280(9):7409-12. DOI: 10.1074/jbc.R400029200. View

3.
Azad N, Zahnow C, Rudin C, Baylin S . The future of epigenetic therapy in solid tumours--lessons from the past. Nat Rev Clin Oncol. 2013; 10(5):256-66. PMC: 3730253. DOI: 10.1038/nrclinonc.2013.42. View

4.
Vignali D, Collison L, Workman C . How regulatory T cells work. Nat Rev Immunol. 2008; 8(7):523-32. PMC: 2665249. DOI: 10.1038/nri2343. View

5.
Derynck R, Zhang Y . Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003; 425(6958):577-84. DOI: 10.1038/nature02006. View