» Articles » PMID: 2413205

Recombinant Human Gamma-interferon in Primary Hepatocellular Carcinoma

Overview
Journal J R Soc Med
Specialty General Medicine
Date 1985 Oct 1
PMID 2413205
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

A phase II trial of recombinant human gamma-interferon in the treatment of unresectable primary hepatocellular carcinoma is reported. The trial was terminated prematurely after recruitment of only 7 patients because of unacceptable toxicity, predominantly renal. There was no evidence of response in any of the 7 patients but some evidence that disease progression was more rapid during the treatment period.

Citing Articles

Rapid growth of hepatocellular carcinoma after or during interferon treatment of chronic hepatitis C: report of three cases.

ONITSUKA A, Yamada N, Yasuda H, Miyata T, Kachi T Surg Today. 1996; 26(2):126-30.

PMID: 8919284 DOI: 10.1007/BF00311777.


Intraarterial combined immunochemotherapy for unresectable hepatocellular carcinoma: preliminary results.

Oka M, Hazama S, Yoshino S, Shimoda K, Suzuki M, Shimizu R Cancer Immunol Immunother. 1994; 38(3):194-200.

PMID: 8124688 PMC: 11037984. DOI: 10.1007/BF01525641.


Interferon-gamma and cytotoxic agents studied in combination using a soft agarose human tumor clonogenic assay.

Saito T, Berens M, Welander C Cancer Chemother Pharmacol. 1987; 19(3):233-9.

PMID: 3107848 DOI: 10.1007/BF00252978.

References
1.
Crane Jr J, Glasgow L, Kern E, Youngner J . Inhibition of murine osteogenic sarcomas by treatment with type I or type II interferon. J Natl Cancer Inst. 1978; 61(3):871-4. View

2.
Miller A, Hoogstraten B, STAQUET M, Winkler A . Reporting results of cancer treatment. Cancer. 1981; 47(1):207-14. DOI: 10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6. View

3.
Wilkinson S . The kidney and liver diseases. J Clin Pathol. 1981; 34(11):1241-4. PMC: 494473. DOI: 10.1136/jcp.34.11.1241. View

4.
Son K, Kew M, Rabson A . Depressed natural killer cell activity in patients with hepatocellular carcinoma. In vitro effects of interferon and levamisole. Cancer. 1982; 50(12):2820-5. DOI: 10.1002/1097-0142(19821215)50:12<2820::aid-cncr2820501222>3.0.co;2-#. View

5.
Rinderknecht E, OConnor B, Rodriguez H . Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation. J Biol Chem. 1984; 259(11):6790-7. View