Genes on Different Chromosomes Influence the Antibody Response to Bacterial Antigens

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1985 Jan 1

PMID 2412957

Citations 3

Authors

P J Baker

D W Bailey

M B Fauntleroy

P W STASHAK

G Caldes

B PRESCOTT

Affiliations

Soon will be listed here.

Abstract

B6.C congenic strains of mice, possessing histocompatibility (H) alleles from high responding BALB/cBy (C) mice on the genetic background of low responding C57BL/6By (B6) mice, were assayed for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha(1----3) epitope of bacterial (Leuconostoc) dextran B-1355. The results affirmed that the antibody response to SSS-III is multigenic and that genes making a positive contribution to responsiveness are located on different chromosomes, i.e., chromosomes 1, 3, 4, 5, and 9. At least one other gene also influences responsiveness to SSS-III; it is linked to the H-17 locus, which has not yet been assigned to a specific chromosome. Genes on chromosomes 1, 4, and 5 influence the magnitude of the antibody response to dextran B-1355. Some of these genes may be antigen-specific in their mode of action; however, others may not since they appear to exert a positive influence on the antibody response to both SSS-III and dextran B-1355.

Citing Articles

Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine.

McCool T, Schreiber J, Greenspan N Infect Immun. 2003; 71(9):5402-6.

PMID: 12933893 PMC: 187339. DOI: 10.1128/IAI.71.9.5402-5406.2003.

Genetic control of the humoral response to cryptococcal capsular polysaccharide in mice.

Dromer F, Yeni P, Charreire J Immunogenetics. 1988; 28(6):417-24.

PMID: 2460403 DOI: 10.1007/BF00355373.

Genetic control of serum antibody responses of inbred mice to type 1 and type 2 fimbriae from Actinomyces viscosus T14V.

Haber J, Grinnell C, Beem J, Clark W Infect Immun. 1991; 59(7):2364-9.

PMID: 1675628 PMC: 258019. DOI: 10.1128/iai.59.7.2364-2369.1991.

References

Durda P, Boos S, Gottlieb P . T100: a new murine cell surface glycoprotein detected by anti-Lyt-2.1 serum. J Immunol. 1979; 122(4):1407-12. View

Jones J, Amsbaugh D, PRESCOTT B . Kinetics of the antibody response to type III pneumococcal polysaccharide (SSS-III). I. Use of 125I-labeled SSS-III to study serum antibody levels, as well as the distribution and excretion of antigen after immunization. J Immunol. 1976; 116(1):41-51. View

Baker P, PRESCOTT B . Letter: The basis for conflicting results obtained in studies on the plaque-forming cell response to type III pneumococcal polysaccharide. J Immunol. 1975; 115(3):891-2. View

Riblet R, Blomberg B, Weigert M, Lieberman R, Taylor B, Potter M . Genetics of mouse antibodies. I. Linkage of the dextran response locus, VH-DEX, to allotype. Eur J Immunol. 1975; 5(11):775-7. DOI: 10.1002/eji.1830051109. View

Baker P, STASHAK P, Amsbaugh D, PRESCOTT B . Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response. Immunology. 1971; 20(4):469-80. PMC: 1456005. View

Baker P, Amsbaugh D, PRESCOTT B, STASHAK P . Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. III. Analysis of genes governing the expression of regulatory T cell activity. J Immunogenet. 1976; 3(4):275-86. DOI: 10.1111/j.1744-313x.1976.tb00584.x. View

Baker P . Homeostatic control of antibody responses: a model based on the recognition of cell-associated antibody by regulatory T cells. Transplant Rev. 1975; 26:3-20. DOI: 10.1111/j.1600-065x.1975.tb00172.x. View

Taylor C, STASHAK P, Caldes G, PRESCOTT B, Chused T, Brooks A . Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide. J Exp Med. 1983; 158(3):703-17. PMC: 2187111. DOI: 10.1084/jem.158.3.703. View

Baker P, Amsbaugh D, STASHAK P, Caldes G, PRESCOTT B . Regulation of the antibody response to pneumococcal polysaccharide by thymus-derived cells. Rev Infect Dis. 1981; 3(2):332-41. DOI: 10.1093/clinids/3.2.332. View

10.

Howard J, Courtenay B . Influence of molecular structure on the tolerogenicity of bacterial dextrans. II. The alpha1--3-linked epitope of dextran B1355. Immunology. 1975; 29(4):599-610. PMC: 1446048. View

11.

Baker P, STASHAK P, PRESCOTT B . Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells. Appl Microbiol. 1969; 17(3):422-6. PMC: 377705. DOI: 10.1128/am.17.3.422-426.1969. View

12.

Lusis A, Taylor B, Wangenstein R, LeBoeuf R . Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983; 258(8):5071-8. View

13.

Blomberg B, Geckeler W, Weigert M . Genetics of the antibody response to dextran in mice. Science. 1972; 177(4044):178-80. DOI: 10.1126/science.177.4044.178. View

14.

Rosenstreich D, Weinblatt A, OBrien A . Genetic control of resistance to infection in mice. Crit Rev Immunol. 1982; 3(4):263-330. View

15.

Gottlieb C . Application of transformations to normalize the distribution of plaque-forming cells. J Immunol. 1974; 113(1):51-7. View

16.

Mobraaten L, BUNKER H, DEMAEYER-GUIGNARD J, DEMAEYER E, Bailey D . Location of histocompatibility and interferon loci on chromosome 3 of the mouse. J Hered. 1984; 75(3):233-4. DOI: 10.1093/oxfordjournals.jhered.a109921. View

17.

Baker P, Rudbach J, PRESCOTT B, Caldes G, Evans C, STASHAK P . Influence of multiple genes on the magnitude of the antibody response to bacterial polysaccharide antigens. Infect Immun. 1984; 45(1):56-61. PMC: 263263. DOI: 10.1128/iai.45.1.56-61.1984. View

18.

Taylor C, STASHAK P, Chiang J, Leiserson W, Caldes G, PRESCOTT B . Characteristics of amplifier T cells involved in the antibody response to the capsular polysaccharide of type III Streptococcus pneumoniae. J Immunol. 1984; 132(6):3103-8. View