Periprosthetic Osteolysis After Total Hip Replacement: Molecular Pathology and Clinical Management

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2013 Oct 16

PMID 24127125

Citations 17

Authors

Donald W Howie

Susan D Neale

David R Haynes

Oksana T Holubowycz

Margaret A McGee

Lucian B Solomon

Stuart A Callary

Gerald J Atkins

David M Findlay

Affiliations

Soon will be listed here.

Abstract

Periprosthetic osteolysis is a serious complication of total hip replacement (THR) in the medium to long term. Although often asymptomatic, osteolysis can lead to prosthesis loosening and periprosthetic fracture. These complications cause significant morbidity and require complex revision surgery. Here, we review advances in our understanding of the cell and tissue response to particles produced by wear of the articular and non-articular surfaces of prostheses. We discuss the molecular and cellular regulators of osteoclast formation and bone resorptive activity, a better understanding of which may lead to pharmacological treatments for periprosthetic osteolysis. We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. Finally, there have been advances in the materials used for bearing surfaces to minimise wear, and we review the literature regarding the performance of these new materials to date.

Citing Articles

Alterations in Small Non-coding MicroRNAs (miRNAs) and the Potential Role in the Development of Aseptic Loosening After Total Hip Replacement: Study Protocol for an Observational, Cross-Sectional Study.

Papagiannis S, Tatani I, Kyriakopoulos G, Kokkalis Z, Megas P, Stathopoulos C Cureus. 2024; 16(10):e72179.

PMID: 39583487 PMC: 11582946. DOI: 10.7759/cureus.72179.

Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis.

de Souza W, Gemini-Piperni S, Ruivo C, Bastos N, Almeida S, Lopes D Mater Today Bio. 2024; 28:101189.

PMID: 39221219 PMC: 11364904. DOI: 10.1016/j.mtbio.2024.101189.

Outcome and complication rate of total hip arthroplasty in patients younger than twenty years: which bearing surface should be used?.

Kang S, Ko Y, Kim H, Yoo J Int Orthop. 2024; 48(6):1381-1390.

PMID: 38217722 PMC: 11076316. DOI: 10.1007/s00264-023-06086-0.

Biomarkers to discriminate between aseptic loosened and stable total hip or knee arthroplasties: a systematic review.

Hasan S, van Schie P, Kaptein B, Schoones J, Marang-van de Mheen P, Nelissen R EFORT Open Rev. 2024; 9(1):25-39.

PMID: 38193539 PMC: 10823569. DOI: 10.1530/EOR-22-0046.

Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis.

Duan J, Hu X, Li T, Wu G, Dou P, Ouyang Z Front Pharmacol. 2021; 12:724256.

PMID: 34658863 PMC: 8511420. DOI: 10.3389/fphar.2021.724256.

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