Hydrogen Peroxide As a Damage Signal in Tissue Injury and Inflammation: Murderer, Mediator, or Messenger?

Overview

Journal J Cell Biochem

Specialties Biochemistry
Cell Biology

Date 2013 Oct 15

PMID 24122865

Citations 74

Authors

Albert van der Vliet

Yvonne M W Janssen-Heininger

Affiliations

Soon will be listed here.

Abstract

Tissue injury and inflammation are associated with increased production of reactive oxygen species (ROS), which have the ability to induce oxidative injury to various biomolecules resulting in protein dysfunction, genetic instability, or cell death. However, recent observations indicate that formation of hydrogen peroxide (H2 O2 ) during tissue injury is also an essential feature of the ensuing wound healing response, and functions as an early damage signal to control several critical aspects of the wound healing process. Because innate oxidative wound responses must be tightly coordinated to avoid chronic inflammation or tissue injury, a more complete understanding is needed regarding the origins and dynamics of ROS production, and their critical biological targets. This prospect highlights the current experimental evidence implicating H2 O2 in early epithelial wound responses, and summarizes technical advances and approaches that may help distinguish its beneficial actions from its more deleterious actions in conditions of chronic tissue injury or inflammation.

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References

Gorissen S, Hristova M, Habibovic A, Sipsey L, Spiess P, Janssen-Heininger Y . Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury. Am J Respir Cell Mol Biol. 2012; 48(3):337-45. PMC: 3604089. DOI: 10.1165/rcmb.2012-0393OC. View

Deng Q, Harvie E, Huttenlocher A . Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol. 2011; 14(4):517-28. PMC: 3302966. DOI: 10.1111/j.1462-5822.2011.01738.x. View

Sakai J, Li J, Subramanian K, Mondal S, Bajrami B, Hattori H . Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012; 37(6):1037-49. PMC: 3525814. DOI: 10.1016/j.immuni.2012.08.017. View

Qian J, Wani R, Klomsiri C, Poole L, Tsang A, Furdui C . A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes. Chem Commun (Camb). 2012; 48(34):4091-3. PMC: 3568515. DOI: 10.1039/c2cc17868k. View

Ha E, Oh C, Bae Y, Lee W . A direct role for dual oxidase in Drosophila gut immunity. Science. 2005; 310(5749):847-50. DOI: 10.1126/science.1117311. View

Roos G, Messens J . Protein sulfenic acid formation: from cellular damage to redox regulation. Free Radic Biol Med. 2011; 51(2):314-26. DOI: 10.1016/j.freeradbiomed.2011.04.031. View

Fialkow L, Wang Y, Downey G . Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 2006; 42(2):153-64. DOI: 10.1016/j.freeradbiomed.2006.09.030. View

Senga T, Hasegawa H, Tanaka M, Rahman M, Ito S, Hamaguchi M . The cysteine-cluster motif of c-Src: its role for the heavy metal-mediated activation of kinase. Cancer Sci. 2008; 99(3):571-5. PMC: 11158444. DOI: 10.1111/j.1349-7006.2007.00714.x. View

van der Vliet A, Bove P . Purinergic signaling in wound healing and airway remodeling. Subcell Biochem. 2011; 55:139-57. DOI: 10.1007/978-94-007-1217-1_6. View

10.

Lee K, Kim S, Kim E, Ha E, You H, Kim B . Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila. Cell. 2013; 153(4):797-811. DOI: 10.1016/j.cell.2013.04.009. View

11.

Evangelista A, Thompson M, Weisbrod R, Pimental D, Tong X, Bolotina V . Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012; 17(8):1099-108. PMC: 3423867. DOI: 10.1089/ars.2011.4022. View

12.

Nathan C . Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006; 6(3):173-82. DOI: 10.1038/nri1785. View

13.

Gauron C, Rampon C, Bouzaffour M, Ipendey E, Teillon J, Volovitch M . Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Sci Rep. 2013; 3:2084. PMC: 3694286. DOI: 10.1038/srep02084. View

14.

Roy S, Khanna S, Nallu K, Hunt T, Sen C . Dermal wound healing is subject to redox control. Mol Ther. 2005; 13(1):211-20. PMC: 1389791. DOI: 10.1016/j.ymthe.2005.07.684. View

15.

Niethammer P, Grabher C, Look A, Mitchison T . A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009; 459(7249):996-9. PMC: 2803098. DOI: 10.1038/nature08119. View

16.

Schafer M, Werner S . Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008; 58(2):165-71. DOI: 10.1016/j.phrs.2008.06.004. View

17.

Koh T, DiPietro L . Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med. 2011; 13:e23. PMC: 3596046. DOI: 10.1017/S1462399411001943. View

18.

Love N, Chen Y, Ishibashi S, Kritsiligkou P, Lea R, Koh Y . Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. Nat Cell Biol. 2013; 15(2):222-8. PMC: 3728553. DOI: 10.1038/ncb2659. View

19.

Allaoui A, Botteaux A, Dumont J, Hoste C, De Deken X . Dual oxidases and hydrogen peroxide in a complex dialogue between host mucosae and bacteria. Trends Mol Med. 2009; 15(12):571-9. DOI: 10.1016/j.molmed.2009.10.003. View

20.

Ushio-Fukai M . Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal. 2008; 11(6):1289-99. PMC: 2842113. DOI: 10.1089/ars.2008.2333. View