Effects of Docosahexaenoic Acid on Neurotransmission

Overview

Journal Biomol Ther (Seoul)

Specialty Pharmacology

Date 2013 Oct 12

PMID 24116288

Citations 36

Authors

Kazuhiro Tanaka

Akhlaq A Farooqui

Nikhat J Siddiqi

Abdullah S Alhomida

Wei-Yi Ong

Affiliations

Soon will be listed here.

Abstract

Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. Changes in DHA content of neuronal membranes lead to functional changes in the activity of receptors and other proteins which might be associated with synaptic function. Accumulating evidence suggests the beneficial effects of dietary DHA supplementation on neurotransmission. This article reviews the beneficial effects of DHA on the brain; uptake, incorporation and release of DHA at synapses, effects of DHA on synapses, effects of DHA on neurotransmitters, DHA metabolites, and changes in DHA with age. Further studies to better understand the metabolome of DHA could result in more effective use of this molecule for treatment of neurodegenerative or neuropsychiatric diseases.

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