Efficacy of Dimetinden and Hydroxyzine/chlorpheniramine in Atopic Dogs: a Randomised, Controlled, Double-blinded Trial

Overview

Journal Vet Rec

Publisher Wiley

Specialty Veterinary Medicine

Date 2013 Oct 12

PMID 24114734

Citations 7

Authors

M Eichenseer

C Johansen

R S Mueller

Affiliations

Soon will be listed here.

Abstract

Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs. Unfortunately, their clinical benefit is largely unsubstantiated. In a double-blinded, placebo-controlled, cross-over trial, the influence of dimetinden and of a combination of chlorpheniramine and hydroxyzine on pruritus and lesions was evaluated in 19 dogs. They were treated with either product or a placebo orally for 14 days, each time followed by a 14-day washout period. Before and after each period, the dogs were examined and the Canine Atopic Dermatitis Extent and Severity Index (CADESI) determined by a clinician, and the pruritus and general condition by the owner. Dimetinden improved the pruritus significantly (P=0.014) but not the CADESI (P=0.087), the combination of hydroxyzine and chlorpheniramine improved the CADESI (P=0.049) and pruritus (P=0.05) significantly. Ten of 17 dogs improved by more than 25 per cent in pruritus with the combination of hydroxyzine and chlorpheniramine, 12 of 18 with dimetindenmaleate and only 2 of 19 with placebo. Antihistamines can help to reduce pruritus in atopic dogs, but in most cases, the improvement is limited and additional treatment may be needed.

Citing Articles

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References

Kuokkanen K . A new antihistamine hc20-511 compared with dimetinden (fenistil retard) in the treatment of chronic urticaria and other pruritic dermatoses. Acta Allergol. 1975; 30(2-3):73-9. View

Hill P, Lau P, Rybnicek J . Development of an owner-assessed scale to measure the severity of pruritus in dogs. Vet Dermatol. 2007; 18(5):301-8. DOI: 10.1111/j.1365-3164.2007.00616.x. View

Leurs R, Church M, Taglialatela M . H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy. 2002; 32(4):489-98. DOI: 10.1046/j.0954-7894.2002.01314.x. View

Loflath A, von Voigts-Rhetz A, Jaeger K, Schmid M, Kuechenhoff H, Mueller R . The efficacy of a commercial shampoo and whirlpooling in the treatment of canine pruritus - a double-blinded, randomized, placebo-controlled study. Vet Dermatol. 2007; 18(6):427-31. DOI: 10.1111/j.1365-3164.2007.00639.x. View

Steffan J, Favrot C, Mueller R . A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet Dermatol. 2006; 17(1):3-16. DOI: 10.1111/j.1365-3164.2005.00491.x. View

Olivry T, DeBoer D, Griffin C, Halliwell R, Hill P, Hillier A . The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol. 2001; 81(3-4):143-6. DOI: 10.1016/s0165-2427(01)00343-9. View

Loewenstein C, Mueller R . A review of allergen-specific immunotherapy in human and veterinary medicine. Vet Dermatol. 2009; 20(2):84-98. DOI: 10.1111/j.1365-3164.2008.00727.x. View

Olivry T, Sousa C . The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy. Vet Immunol Immunopathol. 2001; 81(3-4):317-22. DOI: 10.1016/s0165-2427(01)00314-2. View

Hill P, Olivry T . The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions. Vet Immunol Immunopathol. 2001; 81(3-4):187-98. DOI: 10.1016/s0165-2427(01)00310-5. View

10.

Olivry T, DeBOER D, Favrot C, Jackson H, Mueller R, Nuttall T . Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Vet Dermatol. 2010; 21(3):233-48. DOI: 10.1111/j.1365-3164.2010.00889.x. View

11.

Bachert C . Histamine--a major role in allergy?. Clin Exp Allergy. 1999; 28 Suppl 6:15-9. DOI: 10.1046/j.1365-2222.1998.0280s6015.x. View

12.

Olivry T, Sousa C . The ACVD task force on canine atopic dermatitis (XIX): general principles of therapy. Vet Immunol Immunopathol. 2001; 81(3-4):311-6. DOI: 10.1016/s0165-2427(01)00347-6. View

13.

Olivry T, Marsella R, Iwasaki T, Mueller R . Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol. 2007; 18(2):78-86. DOI: 10.1111/j.1365-3164.2007.00569.x. View

14.

Scott D, Paradis M . A survey of canine and feline skin disorders seen in a university practice: Small Animal Clinic, University of Montréal, Saint-Hyacinthe, Québec (1987-1988). Can Vet J. 1990; 31(12):830-5. PMC: 1480900. View

15.

Hillier A, Griffin C . The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions?. Vet Immunol Immunopathol. 2001; 81(3-4):227-31. DOI: 10.1016/s0165-2427(01)00302-6. View

16.

Lund E, Armstrong P, Kirk C, Kolar L, Klausner J . Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. J Am Vet Med Assoc. 1999; 214(9):1336-41. View

17.

Schwartz L . Mast cells: function and contents. Curr Opin Immunol. 1994; 6(1):91-7. DOI: 10.1016/0952-7915(94)90039-6. View

18.

Olivry T, Foster A, Mueller R, McEwan N, Chesney C, Williams H . Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials. Vet Dermatol. 2010; 21(1):4-22. DOI: 10.1111/j.1365-3164.2009.00784.x. View

19.

Behrendt H, Ring J . Histamine, antihistamines and atopic eczema. Clin Exp Allergy. 1990; 20 Suppl 4:25-30. DOI: 10.1111/j.1365-2222.1990.tb02473.x. View

20.

DeBoer D, Griffin C . The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy. Vet Immunol Immunopathol. 2001; 81(3-4):323-9. DOI: 10.1016/s0165-2427(01)00306-3. View