» Articles » PMID: 2411420

Interaction of Fibronectin with Its Receptor on Platelets

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 1985 Sep 1
PMID 2411420
Citations 58
Authors
Affiliations
Soon will be listed here.
Abstract

We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts directly with glycoprotein IIIa at the platelet cell surface. Both binding and cross-linking of this domain to platelets are competed by a hexapeptide previously shown to block fibroblast adhesion to fibronectin. Finally, we show that a complex of the platelet glycoproteins IIIa and IIb binds to affinity columns of a cell-attachment fragment of fibronectin. These results localize a major fibronectin-platelet interaction to a specific domain of fibronectin and to a specific platelet glycoprotein.

Citing Articles

Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications.

Bonadio J, Bashiri G, Halligan P, Kegel M, Ahmed F, Wang K Adv Drug Deliv Rev. 2024; 209:115303.

PMID: 38588958 PMC: 11111362. DOI: 10.1016/j.addr.2024.115303.


Myosin light chain 6 (Myl6) interacts with kindlin-3 and is required to support integrin αβ activation in platelets in mice.

Xu Z, Zhou Y, Yu H, Chen X, Ma Y J Thromb Haemost. 2024; 22(7):2009-2017.

PMID: 38266679 PMC: 11214885. DOI: 10.1016/j.jtha.2024.01.007.


Richard Hynes, Erkki Ruoslahti, and Timothy Springer receive Lasker prize for pioneering work on integrins.

Munshi H J Clin Invest. 2022; 132(19).

PMID: 36169028 PMC: 9529252. DOI: 10.1172/JCI164374.


Peptide-Based Strategies for Targeted Tumor Treatment and Imaging.

Ayo A, Laakkonen P Pharmaceutics. 2021; 13(4).

PMID: 33918106 PMC: 8065807. DOI: 10.3390/pharmaceutics13040481.


Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine.

Chowdhury F, Huang B, Wang N Cytoskeleton (Hoboken). 2021; 78(6):249-276.

PMID: 33754478 PMC: 8518377. DOI: 10.1002/cm.21658.