Inhibition of Hydrochloric Acid and Pepsin Secretion from Gastric Pouches by Antral Pouch Acidification in Sheep

Overview

Journal J Physiol

Specialty Physiology

Date 1977 Dec 1

PMID 24114

Authors

L M McLeay

D A TITCHEN

Affiliations

Soon will be listed here.

Abstract

1. Secretion of acid and pepsin from separated pouches of the body of the abomasum was studied in sheep during perfusion of antral pouches with acid solutions. 2. Resting secretion of acid and pepsin was reduced by acidification of antral pouches to pH 2.7 or less. 3. Increases in the secretion of HCl and pepsin normally obtained on feeding were reduced or abolished by perfusion of antral pouches with solutions at pH 1.3--2.0. 4. Perfusion of antral pouches with acetylcholine at pH 2.5 failed to stimulate acid secretion as it did at a higher pH. 5. Pentagastrin stimulated acid and pepsin secretion during the inhibition of secretion produced by antral pouch acidification. 6. Increases in reticular motility occurred on antral pouch acidification with solutions of pH 1.1--1.3. 7. The contribution of antral pH in regulating abomasal acid secretion is discussed.

References

McLeay L, TITCHEN D . Gastric, antral and fundic pouch secretion in sheep. J Physiol. 1975; 248(3):595-612. PMC: 1309541. DOI: 10.1113/jphysiol.1975.sp010990. View

TITCHEN D . Reflex contractions of the reticulum. J Physiol. 1953; 122(Suppl):32P. View

Iggo A . Gastric mucosal chemoreceptors with vagal afferent fibres in the cat. Q J Exp Physiol Cogn Med Sci. 1957; 42(4):398-409. DOI: 10.1113/expphysiol.1957.sp001284. View

TITCHEN D . Reflex stimulation and inhibition of reticulum contractions in the ruminant stomach. J Physiol. 1958; 141(1):1-21. PMC: 1358811. DOI: 10.1113/jphysiol.1958.sp005950. View

ASH R . Stimuli influencing the secretion of acid by the abomasum of sheep. J Physiol. 1961; 157:185-207. PMC: 1359925. DOI: 10.1113/jphysiol.1961.sp006714. View

Hill K . Abomasal secretion in the sheep. J Physiol. 1960; 154:115-32. PMC: 1359788. DOI: 10.1113/jphysiol.1960.sp006567. View

Harrison F, Hill K . Digestive secretions and the flow of digesta along the duodenum of the sheep. J Physiol. 1962; 162:225-43. PMC: 1359653. DOI: 10.1113/jphysiol.1962.sp006928. View

McLeay L, TITCHEN D . Acid and pepsin secretion of separated gastric pouches during perfusion of antral pouches with cholinergic stimulating and blocking agents and lignocaine. J Physiol. 1977; 264(1):215-27. PMC: 1307754. DOI: 10.1113/jphysiol.1977.sp011664. View

McLeay L, Anderson N, BINGLEY J, TITCHEN D . Effects on abomasal function of Ostertagia circumcincta infections in sheep. Parasitology. 1973; 66(2):241-57. DOI: 10.1017/s0031182000045182. View

10.

McLeay L, TITCHEN D . Effects of the amount and type of food eaten on secretion from fundic abomasal pouches of sheep. Br J Nutr. 1974; 32(2):375-87. DOI: 10.1079/bjn19740089. View

11.

Becker H, Reeder D, Thompson J . The effect of changes in antral pH on the basal release of gastrin. Proc Soc Exp Biol Med. 1973; 143(1):238-40. DOI: 10.3181/00379727-143-37293. View

12.

Debas H, Konturek S, Walsh J, GROSSMAN M . Proof of a pyloro-oxyntic reflex for stimulation of acid secretion. Gastroenterology. 1974; 66(4):526-32. View

13.

McLeay L, TITCHEN D . Abomasal secretory responses to teasing with food and feeding in the sheep. J Physiol. 1970; 206(3):605-28. PMC: 1348668. DOI: 10.1113/jphysiol.1970.sp009033. View

14.

Amure B, Omole A . Comparative study of antral gastrin activity in some mammals. Br J Pharmacol. 1971; 41(4):629-39. PMC: 1702769. DOI: 10.1111/j.1476-5381.1971.tb07071.x. View

15.

POSEY Jr E, Franklin H . Relation of antral pH to gastrin release and fundal pH in dogs. Am J Dig Dis. 1967; 12(4):356-62. DOI: 10.1007/BF02241937. View

16.

Jury D, McLeay L . Gastrin-like activity in the forestomach, abomasum and intestine of the sheep [proceedings]. J Physiol. 1977; 265(1):57P-58P. View