» Articles » PMID: 24105342

Molecular Logic of Neocortical Projection Neuron Specification, Development and Diversity

Overview
Specialty Neurology
Date 2013 Oct 10
PMID 24105342
Citations 447
Authors
Affiliations
Soon will be listed here.
Abstract

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.

Citing Articles

Geometric influences on the regional organization of the mammalian brain.

Pang J, Robinson P, Aquino K, Levi P, Holmes A, Markicevic M bioRxiv. 2025; .

PMID: 39975401 PMC: 11838429. DOI: 10.1101/2025.01.30.635820.


mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis.

Serdar L, Egol J, Lackford B, Bennett B, Hu G, Silver D PLoS Biol. 2025; 23(2):e3003031.

PMID: 39913536 PMC: 11838918. DOI: 10.1371/journal.pbio.3003031.


Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.

Sudarsanam S, Guzman-Clavel L, Dar N, Ziak J, Shahid N, Jin X bioRxiv. 2025; .

PMID: 39896513 PMC: 11785193. DOI: 10.1101/2025.01.22.634300.


A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.

Flores M, Garcia-Forn M, von Mueffling A, Ola P, Park Y, Boitnott A Biol Open. 2025; 14(1).

PMID: 39878593 PMC: 11815569. DOI: 10.1242/bio.061854.


Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development.

Gao Y, van Velthoven C, Lee C, Thomas E, Bertagnolli D, Carey D bioRxiv. 2025; .

PMID: 39829740 PMC: 11741437. DOI: 10.1101/2024.10.02.616246.


References
1.
Kowalczyk T, Pontious A, Englund C, Daza R, Bedogni F, Hodge R . Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex. Cereb Cortex. 2009; 19(10):2439-50. PMC: 2742596. DOI: 10.1093/cercor/bhn260. View

2.
Wang X, Tsai J, LaMonica B, Kriegstein A . A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci. 2011; 14(5):555-61. PMC: 3083489. DOI: 10.1038/nn.2807. View

3.
Shim S, Kwan K, Li M, Lefebvre V, Sestan N . Cis-regulatory control of corticospinal system development and evolution. Nature. 2012; 486(7401):74-9. PMC: 3375921. DOI: 10.1038/nature11094. View

4.
Bishop K, Goudreau G, OLeary D . Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science. 2000; 288(5464):344-9. DOI: 10.1126/science.288.5464.344. View

5.
Zhou C, Tsai S, Tsai M . COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev. 2001; 15(16):2054-9. PMC: 312763. DOI: 10.1101/gad.913601. View