Carbohydrate Determinants Associated with Carcinoembryonic Antigen (CEA)

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1985 Sep 1

PMID 2410505

Citations 8

Authors

E J Nichols

R Kannagi

S I HAKOMORI

M J Krantz

A Fuks

Affiliations

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Abstract

The reactivities of eight purified preparations of carcinoembryonic antigen with monoclonal antibodies directed to tumor-associated carbohydrate determinants have been studied. All eight preparations showed strong reactivities with AH6, which defines Y structure (Fuc alpha 1----2Gal beta 1----4[Fuc alpha 1----3] GlcNAc beta 1----R), whereas only a few preparations showed reactivity with FH4-defining dimeric X determinants, (Gal beta 1----4 [Fuc alpha 1----3]GlcNAc beta 1----3Gal beta 1----4 [Fuc alpha 1----3]GlcNA beta 1----3Gal beta 1----R). No other antibodies tested showed any reactivity with these preparations. These carbohydrate markers associated with carcinoembryonic antigen will be useful to enhance the diagnostic value of the antigen.

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