Non-structural Proteins of Arthropod-borne Bunyaviruses: Roles and Functions

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2013 Oct 9

PMID 24100888

Citations 34

Authors

Saleh Eifan

Esther Schnettler

Isabelle Dietrich

Alain Kohl

Anne-Lie Blomstrom

Affiliations

Soon will be listed here.

Abstract

Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

Citing Articles

Elucidating the Microsatellite Signature of the Tri-Partite Genomes of the Viral Family Peribunyaviridae.

Vishwakarma A, Nasrin T, Hoque M, Ali S Curr Microbiol. 2025; 82(5):191.

PMID: 40080168 DOI: 10.1007/s00284-025-04177-2.

Emergence of a natural reassortant between Shamonda and Sathuperi viruses of the species Orthobunyavirus schmallenbergense in Japan.

Tomochi H, Mekaru Y, Murota K, Konishi M, Ikeda R, Yanase T Arch Virol. 2025; 170(2):44.

PMID: 39893347 DOI: 10.1007/s00705-025-06233-5.

Evidence of human exposure and associated risk factors to Rift Valley fever in selected districts of Central and Western Zambia.

Kasongamulilo C, Syakalima M, Saasa N, Kainga H, Pandey G, Mukubesa A PLoS One. 2025; 20(1):e0309288.

PMID: 39854363 PMC: 11760628. DOI: 10.1371/journal.pone.0309288.

Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.

Li Z, Duan S, Yu T, Li B, Zhang W, Zhou C Autophagy. 2024; 20(10):2133-2145.

PMID: 38762760 PMC: 11423686. DOI: 10.1080/15548627.2024.2356505.

RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qīnghăi Province, China.

Fang Y, Wang J, Sun J, Su Z, Chen S, Xiao J Virol Sin. 2024; 39(4):537-545.

PMID: 38679334 PMC: 11401450. DOI: 10.1016/j.virs.2024.04.006.

References

Garcia S, Billecocq A, Crance J, Prins M, Garin D, Bouloy M . Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cells. J Gen Virol. 2006; 87(Pt 7):1985-1989. DOI: 10.1099/vir.0.81827-0. View

Fontana J, Lopez-Montero N, Elliott R, Fernandez J, Risco C . The unique architecture of Bunyamwera virus factories around the Golgi complex. Cell Microbiol. 2008; 10(10):2012-28. PMC: 7162186. DOI: 10.1111/j.1462-5822.2008.01184.x. View

Hiscott J . Triggering the innate antiviral response through IRF-3 activation. J Biol Chem. 2007; 282(21):15325-9. DOI: 10.1074/jbc.R700002200. View

Lopez C, Aramburu J, Galipienso L, Soler S, Nuez F, Rubio L . Evolutionary analysis of tomato Sw-5 resistance-breaking isolates of Tomato spotted wilt virus. J Gen Virol. 2010; 92(Pt 1):210-5. DOI: 10.1099/vir.0.026708-0. View

Prins M, Kikkert M, Ismayadi C, de Graauw W, de Haan P, Goldbach R . Characterization of RNA-mediated resistance to tomato spotted wilt virus in transgenic tobacco plants expressing NS(M) gene sequences. Plant Mol Biol. 1997; 33(2):235-43. DOI: 10.1023/a:1005729808191. View

Mansuroglu Z, Josse T, Gilleron J, Billecocq A, Leger P, Bouloy M . Nonstructural NSs protein of rift valley fever virus interacts with pericentromeric DNA sequences of the host cell, inducing chromosome cohesion and segregation defects. J Virol. 2009; 84(2):928-39. PMC: 2798389. DOI: 10.1128/JVI.01165-09. View

Blakqori G, Weber F . Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs. J Virol. 2005; 79(16):10420-8. PMC: 1182624. DOI: 10.1128/JVI.79.16.10420-10428.2005. View

Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L . Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis. 2012; 18(6):963-5. PMC: 3358154. DOI: 10.3201/eid1806.111345. View

Habjan M, Pichlmair A, Elliott R, Overby A, Glatter T, Gstaiger M . NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. J Virol. 2009; 83(9):4365-75. PMC: 2668506. DOI: 10.1128/JVI.02148-08. View

10.

Kalveram B, Ikegami T . Toscana virus NSs protein promotes degradation of double-stranded RNA-dependent protein kinase. J Virol. 2013; 87(7):3710-8. PMC: 3624217. DOI: 10.1128/JVI.02506-12. View

11.

Kallfass C, Ackerman A, Lienenklaus S, Weiss S, Heimrich B, Staeheli P . Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice. J Virol. 2012; 86(20):11223-30. PMC: 3457137. DOI: 10.1128/JVI.01093-12. View

12.

Nagata T, Inoue-Nagata A, Smid H, Goldbach R, Peters D . Tissue tropism related to vector competence of Frankliniella occidentalis for tomato spotted wilt tospovirus. J Gen Virol. 1999; 80 ( Pt 2):507-515. DOI: 10.1099/0022-1317-80-2-507. View

13.

Huang N, Lin C, Lin Y, Yu W . Modulation of YY1 activity by SAP30. Biochem Biophys Res Commun. 2003; 306(1):267-75. DOI: 10.1016/s0006-291x(03)00966-5. View

14.

Benferhat R, Josse T, Albaud B, Gentien D, Mansuroglu Z, Marcato V . Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome. J Virol. 2012; 86(20):11333-44. PMC: 3457170. DOI: 10.1128/JVI.01549-12. View

15.

Ye J, Cippitelli M, Dorman L, Ortaldo J, Young H . The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol. 1996; 16(9):4744-53. PMC: 231475. DOI: 10.1128/MCB.16.9.4744. View

16.

Pantaleo V . Plant RNA silencing in viral defence. Adv Exp Med Biol. 2011; 722:39-58. DOI: 10.1007/978-1-4614-0332-6_3. View

17.

Kormelink R, Kitajima E, de Haan P, Zuidema D, Peters D, Goldbach R . The nonstructural protein (NSs) encoded by the ambisense S RNA segment of tomato spotted wilt virus is associated with fibrous structures in infected plant cells. Virology. 1991; 181(2):459-68. DOI: 10.1016/0042-6822(91)90878-f. View

18.

Ikegami T, Makino S . The pathogenesis of Rift Valley fever. Viruses. 2011; 3(5):493-519. PMC: 3111045. DOI: 10.3390/v3050493. View

19.

Chattopadhyay S, Marques J, Yamashita M, Peters K, Smith K, Desai A . Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J. 2010; 29(10):1762-73. PMC: 2876960. DOI: 10.1038/emboj.2010.50. View

20.

Colon-Ramos D, Irusta P, Gan E, Olson M, Song J, Morimoto R . Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell. 2003; 14(10):4162-72. PMC: 207008. DOI: 10.1091/mbc.e03-03-0139. View