Chlorogenic Acid Inhibits the Replication and Viability of Enterovirus 71 in Vitro

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Oct 8

PMID 24098754

Citations 22

Authors

Xiang Li

Yuanyuan Liu

Xueling Hou

Hongjun Peng

Li Zhang

Qingbo Jiang

Mei Shi

Yun Ji

Yuyue Wang

Weifeng Shi

Affiliations

Soon will be listed here.

Abstract

Enterovirus 71 (EV71) is an etiology for a number of diseases in humans. Traditional Chinese herbs have been reported to be effective for treating EV71 infection. However, there is no report about the antiviral effects of CHA against EV71. In this study, plaque reduction assay demonstrated that the inhibitory concentration 50% (IC50) of CHA on EV71 replication is 6.3 µg/ml. When both CHA (20 µg/ml) and EV71 were added, or added post-infection at different time points, CHA was able to effectively inhibit EV71 replication between 0 and 10 h. In addition, CHA inhibited EV71 2A transcription and translation in EV71-infected RD cells, but did not affect VP1, 3C, and 3D expression. Furthermore, CHA inhibited secretions of IL-6, TNF-α, IFN-γ and MCP-1 in EV71-infected RD cells. Altogether, these results revealed that CHA may have antiviral properties for treating EV71 infection.

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