Effect of Hepatitis C Infection on HIV-induced Apoptosis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Oct 8

PMID 24098405

Citations 6

Authors

Tomasz Laskus

Karen V Kibler

Marcin Chmielewski

Jeffrey Wilkinson

Debra Adair

Andrzej Horban

Grzegorz Stanczak

Marek Radkowski

Affiliations

Soon will be listed here.

Abstract

Background: Hepatitis C virus (HCV) coinfection was reported to negatively affect HIV disease and HIV infection has a deleterious effect on HCV-related liver disease. However, despite common occurrence of HCV/HIV coinfection little is known about the mechanisms of interactions between the two viruses.

Methods: We studied CD4+ and CD8+ T cell and CD19+ B cell apoptosis in 104 HIV-positive patients (56 were also HCV-positive) and in 22 HCV/HIV-coinfected patients treated for chronic hepatitis C with pegylated interferon and ribavirin. We also analyzed HCV/HIV coinfection in a Daudi B-cell line expressing CD4 and susceptible to both HCV and HIV infection. Apoptosis was measured by AnnexinV staining.

Results: HCV/HIV coinfected patients had lower CD4+ and CD8+ T cell apoptosis and higher CD19+ B cell apoptosis than those with HIV monoinfection. Furthermore, anti-HCV treatment of HCV/HIV coinfected patients was followed by an increase of CD4+ and CD8+ T cell apoptosis and a decrease of CD19+ B cell apoptosis. In the Daudi CD4+ cell line, presence of HCV infection facilitated HIV replication, however, decreased the rate of HIV-related cell death.

Conclusion: In HCV/HIV coinfected patients T-cells were found to be destroyed at a slower rate than in HIV monoinfected patients. These results suggest that HCV is a molecular-level determinant in HIV disease.

Citing Articles

Both HCV Infection and Elevated Liver Stiffness Significantly Impacts on Several Parameters of T-Cells Homeostasis in HIV-Infected Patients.

Restrepo C, Alvarez B, Valencia J, Garcia M, Navarrete-Munoz M, Ligos J J Clin Med. 2020; 9(9).

PMID: 32942736 PMC: 7564456. DOI: 10.3390/jcm9092978.

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil.

Tizzot M, Lidani K, Andrade F, Weinschutz Mendes H, Beltrame M, Reiche E Front Immunol. 2018; 9:2292.

PMID: 30349535 PMC: 6187973. DOI: 10.3389/fimmu.2018.02292.

Human T Lymphocytes Are Permissive for Dengue Virus Replication.

Silveira G, Wowk P, Cataneo A, Dos Santos P, Delgobo M, Stimamiglio M J Virol. 2018; 92(10).

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HCV coinfection contributes to HIV pathogenesis by increasing immune exhaustion in CD8 T-cells.

Rallon N, Garcia M, Garcia-Samaniego J, Rodriguez N, Cabello A, Restrepo C PLoS One. 2017; 12(3):e0173943.

PMID: 28323897 PMC: 5360268. DOI: 10.1371/journal.pone.0173943.

Differential regulation of cytotoxicity pathway discriminating between HIV, HCV mono- and co-infection identified by transcriptome profiling of PBMCs.

Wu J, Saksena M, Soriano V, Vispo E, Saksena N Virol J. 2015; 12:4.

PMID: 25623235 PMC: 4312599. DOI: 10.1186/s12985-014-0236-6.

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