Normal Cognitive Aging

Overview

Journal Clin Geriatr Med

Specialty Geriatrics

Date 2013 Oct 8

PMID 24094294

Citations 721

Authors

Caroline N Harada

Marissa C Natelson Love

Kristen L Triebel

Affiliations

Soon will be listed here.

Abstract

Even those who do not experience dementia or mild cognitive impairment may experience subtle cognitive changes associated with aging. Normal cognitive changes can affect an older adult's everyday function and quality of life, and a better understanding of this process may help clinicians distinguish normal from disease states. This article describes the neurocognitive changes observed in normal aging, followed by a description of the structural and functional alterations seen in aging brains. Practical implications of normal cognitive aging are then discussed, followed by a discussion of what is known about factors that may mitigate age-associated cognitive decline.

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References

Whiting 4th W, Smith A . Differential age-related processing limitations in recall and recognition tasks. Psychol Aging. 1997; 12(2):216-24. DOI: 10.1037//0882-7974.12.2.216. View

Salat D, Kaye J, Janowsky J . Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch Neurol. 1999; 56(3):338-44. DOI: 10.1001/archneur.56.3.338. View

Wisdom N, Mignogna J, Collins R . Variability in Wechsler Adult Intelligence Scale-IV subtest performance across age. Arch Clin Neuropsychol. 2012; 27(4):389-97. DOI: 10.1093/arclin/acs041. View

Taylor J, Kennedy Q, Noda A, Yesavage J . Pilot age and expertise predict flight simulator performance: a 3-year longitudinal study. Neurology. 2007; 68(9):648-54. PMC: 2907140. DOI: 10.1212/01.wnl.0000255943.10045.c0. View

Zec R, Markwell S, Burkett N, Larsen D . A longitudinal study of confrontation naming in the "normal" elderly. J Int Neuropsychol Soc. 2005; 11(6):716-26. DOI: 10.1017/S1355617705050897. View

Raz N, Head D, Dupuis J, Acker J . Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging. Neuropsychology. 1998; 12(1):95-114. DOI: 10.1037//0894-4105.12.1.95. View

Ball K, Edwards J, Ross L . The impact of speed of processing training on cognitive and everyday functions. J Gerontol B Psychol Sci Soc Sci. 2007; 62 Spec No 1:19-31. DOI: 10.1093/geronb/62.special_issue_1.19. View

Stern Y, Gurland B, Tatemichi T, Tang M, Wilder D, Mayeux R . Influence of education and occupation on the incidence of Alzheimer's disease. JAMA. 1994; 271(13):1004-10. View

Minder C, Muller T, Gillmann G, Beck J, Stuck A . Subgroups of refusers in a disability prevention trial in older adults: baseline and follow-up analysis. Am J Public Health. 2002; 92(3):445-50. PMC: 1447097. DOI: 10.2105/ajph.92.3.445. View

10.

Haaland K, Price L, LaRue A . What does the WMS-III tell us about memory changes with normal aging?. J Int Neuropsychol Soc. 2003; 9(1):89-96. DOI: 10.1017/s1355617703910101. View

11.

Schaie K, Willis S, OHanlon A . Perceived intellectual performance change over seven years. J Gerontol. 1994; 49(3):P108-18. DOI: 10.1093/geronj/49.3.p108. View

12.

Cabeza R, Anderson N, Locantore J, McIntosh A . Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage. 2002; 17(3):1394-402. DOI: 10.1006/nimg.2002.1280. View

13.

Marshall S, Demmings E, Woolnough A, Salim D, Man-Son-Hing M . Determining fitness to drive in older persons: a survey of medical and surgical specialists. Can Geriatr J. 2012; 15(4):101-19. PMC: 3516354. DOI: 10.5770/cgj.15.30. View

14.

Hayden K, Welsh-Bohmer K . Epidemiology of cognitive aging and Alzheimer's disease: contributions of the cache county utah study of memory, health and aging. Curr Top Behav Neurosci. 2011; 10:3-31. DOI: 10.1007/7854_2011_152. View

15.

Oosterman J, Vogels R, van Harten B, Gouw A, Poggesi A, Scheltens P . Assessing mental flexibility: neuroanatomical and neuropsychological correlates of the Trail Making Test in elderly people. Clin Neuropsychol. 2010; 24(2):203-19. DOI: 10.1080/13854040903482848. View

16.

van Beijsterveldt C, van Boxtel M, Bosma H, Houx P, Buntinx F, Jolles J . Predictors of attrition in a longitudinal cognitive aging study: the Maastricht Aging Study (MAAS). J Clin Epidemiol. 2002; 55(3):216-23. DOI: 10.1016/s0895-4356(01)00473-5. View

17.

Darowski E, Helder E, Zacks R, Hasher L, Hambrick D . Age-related differences in cognition: the role of distraction control. Neuropsychology. 2008; 22(5):638-44. DOI: 10.1037/0894-4105.22.5.638. View

18.

Salthouse T, Fristoe N, Lineweaver T, Coon V . Aging of attention: does the ability to divide decline?. Mem Cognit. 1995; 23(1):59-71. DOI: 10.3758/bf03210557. View

19.

Resnick S, Pham D, Kraut M, Zonderman A, Davatzikos C . Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci. 2003; 23(8):3295-301. PMC: 6742337. View

20.

Abner E, Dennis B, Mathews M, Mendiondo M, Caban-Holt A, Kryscio R . Practice effects in a longitudinal, multi-center Alzheimer's disease prevention clinical trial. Trials. 2012; 13:217. PMC: 3543284. DOI: 10.1186/1745-6215-13-217. View