Lack of Effect of Increased Pineal Serotonin Content on H3-tryptophan Uptake

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1975 Jan 1

PMID 240913

Authors

R J Wurtman

H M SHEIN

Affiliations

Soon will be listed here.

Abstract

Major increases in the serotonin concentrations of rat pineal organs were produced by administering Catron, a monoamine oxidase inhibitor, prior to autopsy, or by preincubating the glands with serotonin (3X10-4M). These increases had no effect on pineal uptake of H3-tryptophan, the amino acid precursor for serotonin. These observations provide further evidence that the control of serotonin synthesis involves an important "open-loop" component.

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