Abnormal P600 Word Repetition Effect in Elderly Persons with Preclinical Alzheimer's Disease

Overview

Journal Cogn Neurosci

Specialty Neurology

Date 2013 Oct 5

PMID 24090465

Citations 21

Authors

John M Olichney

Jamie Pak

David P Salmon

Jin-Chen Yang

Tim Gahagan

Ralph Nowacki

Lawrence Hansen

Douglas Galasko

Marta Kutas

Vicente J Iragui-Madoz

Affiliations

Soon will be listed here.

Abstract

We sought cognitive event-related potential (ERP) biomarkers of "Preclinical Alzheimer's disease" (Pre-AD) using an incidental verbal learning paradigm with high sensitivity to prodromal AD. Seven elderly persons, with normal cognition at the time of ERP recordings, but who showed subsequent cognitive decline or AD pathology at autopsy (n = 5, mean Braak stage = 2.8), were compared to 12 "robust" normal elderly (RNE) persons who remained cognitively normal (Mfollow-up = 9.0 years). EEG was recorded during a word repetition paradigm (semantically congruous (50%) and incongruous target words repeat ~10-140 seconds later). The RNE P600 congruous word repetition ERP effects (New minus Old congruous words) were significantly larger than in Pre-AD (mean amplitudes = 3.28 vs. 0.10 μV, p = .04). High group discrimination (84%) was achieved (by a P600 amplitude cutoff of ~1.5 μV). Abnormal P600 word repetition effects in cognitively normal elderly persons may be an important sign of synaptic dysfunction and Preclinical AD.

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