Impact of Botanical Oils on Polyunsaturated Fatty Acid Metabolism and Leukotriene Generation in Mild Asthmatics

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2013 Oct 4

PMID 24088297

Citations 16

Authors

Jonathan P Arm

Joshua A Boyce

Lin Wang

Heng Chhay

Muhammad Zahid

Vaishali Patil

Usha Govindarajulu

Priscilla Ivester

Kelly L Weaver

Susan Sergeant

Elliot Israel

Floyd H Chilton

Affiliations

Soon will be listed here.

Abstract

Background: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including arachidonic acid (AA) metabolism and improve inflammatory disorders.

Methods: The diet of mild asthmatics patients was supplemented for three weeks with varying doses of two botanical seed oils (borage oil [Borago officinalis, BO] and echium seed oil [Echium plantagineum; EO]) that contain SDA, ALA and GLA. A three week wash out period followed. The impact of these dietary manipulations was evaluated for several biochemical endpoints, including in vivo PUFA metabolism and ex vivo leukotriene generation from stimulated leukocytes.

Results: Supplementation with several EO/BO combinations increased circulating 20-22 carbon (20-22C) PUFAs, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and dihommo-gammalinolenic acid (DGLA), which have been shown to inhibit AA metabolism and inflammation without impacting circulating AA levels. BO/EO combinations also inhibited ex vivo leukotriene generation with some combinations attenuating cysteinyl leukotriene generation in stimulated basophils by >50% and in stimulated neutrophils by >35%.

Conclusions: This study shows that dietary supplementation with BO/EO alters 20-22C PUFA levels and attenuates leukotriene production in a manner consistent with a reduction in inflammation.

Citing Articles

Herbal Treatment of COPD and Asthma According to Persian Medicine: a Review of Current Evidence.

Baniamerian R, Tahermohammadi H, Daneshfard B, Agin K, Sadr S, Kaveh S Tanaffos. 2024; 22(2):187-199.

PMID: 38628881 PMC: 11016916.

Neuroprotective Effect of Stearidonic Acid on Amyloid β-Induced Neurotoxicity in Rat Hippocampal Cells.

Li Y, Lai W, Zheng C, Babu J, Xue C, Ai Q Antioxidants (Basel). 2022; 11(12).

PMID: 36552565 PMC: 9774633. DOI: 10.3390/antiox11122357.

Hemp seed significantly modulates the endocannabinoidome and produces beneficial metabolic effects with improved intestinal barrier function and decreased inflammation in mice under a high-fat, high-sucrose diet as compared with linseed.

Ben Necib R, Manca C, Lacroix S, Martin C, Flamand N, Di Marzo V Front Immunol. 2022; 13:882455.

PMID: 36238310 PMC: 9552265. DOI: 10.3389/fimmu.2022.882455.

Drug Repurposing to Treat Glucocorticoid Resistance in Asthma.

Wang A, Panganiban R, Qiu W, Kho A, Chupp G, Meyers D J Pers Med. 2021; 11(3).

PMID: 33802355 PMC: 7999884. DOI: 10.3390/jpm11030175.

Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.

Sergeant S, Hallmark B, Mathias R, Mustin T, Ivester P, Bohannon M Am J Clin Nutr. 2020; 111(5):1068-1078.

PMID: 32167131 PMC: 7198310. DOI: 10.1093/ajcn/nqaa023.

References

Nauseef W . Isolation of human neutrophils from venous blood. Methods Mol Biol. 2008; 412:15-20. DOI: 10.1007/978-1-59745-467-4_2. View

Arm J, HORTON C, Mencia-Huerta J, HOUSE F, Eiser N, Clark T . Effect of dietary supplementation with fish oil lipids on mild asthma. Thorax. 1988; 43(2):84-92. PMC: 1020747. DOI: 10.1136/thx.43.2.84. View

Surette M, Koumenis I, Edens M, Tramposch K, Chilton F . Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects. Clin Ther. 2003; 25(3):948-71. DOI: 10.1016/s0149-2918(03)80116-9. View

Henz B, Jablonska S, van de Kerkhof P, Stingl G, Blaszczyk M, Vandervalk P . Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999; 140(4):685-8. DOI: 10.1046/j.1365-2133.1999.02771.x. View

Lee T, Hoover R, Williams J, Sperling R, Ravalese 3rd J, Spur B . Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med. 1985; 312(19):1217-24. DOI: 10.1056/NEJM198505093121903. View

Arm J, HORTON C, Spur B, Mencia-Huerta J, Lee T . The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma. Am Rev Respir Dis. 1989; 139(6):1395-400. DOI: 10.1164/ajrccm/139.6.1395. View

Mantzioris E, James M, Gibson R, Cleland L . Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr. 1994; 59(6):1304-9. DOI: 10.1093/ajcn/59.6.1304. View

Kapoor R, Huang Y . Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. Curr Pharm Biotechnol. 2006; 7(6):531-4. DOI: 10.2174/138920106779116874. View

Nouri-Aria K, Irani A, Jacobson M, OBrien F, Varga E, Till S . Basophil recruitment and IL-4 production during human allergen-induced late asthma. J Allergy Clin Immunol. 2001; 108(2):205-11. DOI: 10.1067/mai.2001.117175. View

10.

Iversen L, Fogh K, Kragballe K . Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: selective inhibition of the 5-lipoxygenase pathway. Arch Dermatol Res. 1992; 284(4):222-6. DOI: 10.1007/BF00375798. View

11.

Barham J, Edens M, Fonteh A, Johnson M, Easter L, Chilton F . Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr. 2000; 130(8):1925-31. DOI: 10.1093/jn/130.8.1925. View

12.

Arm J, Lee T . Sulphidopeptide leukotrienes in asthma. Clin Sci (Lond). 1993; 84(5):501-10. DOI: 10.1042/cs0840501. View

13.

Calder P . n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006; 83(6 Suppl):1505S-1519S. DOI: 10.1093/ajcn/83.6.1505S. View

14.

Heise C, ODowd B, Figueroa D, Sawyer N, Nguyen T, Im D . Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem. 2000; 275(39):30531-6. DOI: 10.1074/jbc.M003490200. View

15.

Calder P . N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids. 2003; 38(4):343-52. PMC: 7101988. DOI: 10.1007/s11745-003-1068-y. View

16.

Philip G, Malmstrom K, Hampel F, Weinstein S, Laforce C, Ratner P . Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring. Clin Exp Allergy. 2002; 32(7):1020-8. DOI: 10.1046/j.1365-2222.2002.01422.x. View

17.

Lynch K, ONeill G, Liu Q, Im D, Sawyer N, Metters K . Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999; 399(6738):789-93. DOI: 10.1038/21658. View

18.

Surette M, Koumenis I, Edens M, Tramposch K, Clayton B, Bowton D . Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial. Clin Ther. 2003; 25(3):972-9. DOI: 10.1016/s0149-2918(03)80117-0. View

19.

Arisaka M, Arisaka O, Yamashiro Y . Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Prostaglandins Leukot Essent Fatty Acids. 1991; 43(3):197-201. DOI: 10.1016/0952-3278(91)90169-6. View

20.

Milgrom H, Fick Jr R, Su J, Reimann J, Bush R, Watrous M . Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. N Engl J Med. 1999; 341(26):1966-73. DOI: 10.1056/NEJM199912233412603. View