Therapeutic Hepatocyte Transplant for Inherited Metabolic Disorders: Functional Considerations, Recent Outcomes and Future Prospects

Overview

Journal J Inherit Metab Dis

Publisher Wiley

Date 2013 Oct 3

PMID 24085555

Citations 4

Authors

Kara R Vogel

Andrew A Kennedy

Luke A Whitehouse

K Michael Gibson

Affiliations

Soon will be listed here.

Abstract

The applications, outcomes and future strategies of hepatocyte transplantation (HTx) as a corrective intervention for inherited metabolic disease (IMD) are described. An overview of HTx in IMDs, as well as preclinical evaluations in rodent and other mammalian models, is summarized. Current treatments for IMDs are highlighted, along with short- and long-term outcomes and the potential for HTx to supplement or supplant these treatments. Finally, the advantages and disadvantages of HTx are presented, highlighted by long-term challenges with interorgan engraftment and expansion of transplanted cells, in addition to the future prospects of stem cell transplants. At present, the utility of HTx is represented by the potential to bridge patients with life-threatening liver disease to organ transplantation, especially as an adjuvant intervention where severe organ shortages continue to pose challenges.

Citing Articles

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Li X, Wang Y, Yang H, Dai Y Front Immunol. 2022; 12:802692.

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Hepatocyte-like cells derived from induced pluripotent stem cells.

Roy-Chowdhury N, Wang X, Guha C, Roy-Chowdhury J Hepatol Int. 2016; 11(1):54-69.

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Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer.

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Etanercept blocks inflammatory responses orchestrated by TNF-α to promote transplanted cell engraftment and proliferation in rat liver.

Viswanathan P, Kapoor S, Kumaran V, Joseph B, Gupta S Hepatology. 2014; 60(4):1378-88.

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