Idiopathic Intracranial Hypertension; Research Progress and Emerging Themes

Overview

Journal J Neurol

Specialty Neurology

Date 2013 Oct 3

PMID 24085346

Citations 6

Authors

Ruchika Batra

Alexandra Sinclair

Affiliations

Soon will be listed here.

Abstract

Idiopathic intracranial hypertension (IIH) is a condition characterised by increased intracranial pressure of unknown cause predominantly seen in obese women of childbearing age and associated with a history of recent weight gain. The aetiology is poorly understood and there are no evidence-based guidelines on the management of the disease. We aim to provide a review of the recent literature outlining the latest advances in this field over the past few years. Areas of emerging interest related to the pathophysiology of IIH will be discussed, such as the role of obesity, adipose tissue and 11β-hydroxysteroid dehydrogenase type 1. We consider the latest research on the role of venous sinus stenosis in IIH and ex vivo advances into cerebrospinal fluid drainage via the arachnoid granulation tissue. The latest techniques for optic nerve head evaluation and the role of optical coherence tomography will be summarised. Finally, we will discuss recent advances in the management of IIH, including weight loss, and medical and surgical treatment strategies.

Citing Articles

Idiopathic Intracranial Hypertension After Abrupt Cessation of Medication: A Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Cessation and Review of the Literature.

Heckel B Curr Pain Headache Rep. 2024; 28(6):453-456.

PMID: 38573570 PMC: 11156736. DOI: 10.1007/s11916-024-01215-9.

Optical coherence tomography for the diagnosis and monitoring of idiopathic intracranial hypertension.

Albrecht P, Blasberg C, Ringelstein M, Muller A, Finis D, Guthoff R J Neurol. 2017; 264(7):1370-1380.

PMID: 28584914 DOI: 10.1007/s00415-017-8532-x.

Pseudotumor Cerebri and Implanon: Is Rapid Weight Gain the Trigger?.

Kassen N, Wells C, Moodley A Neuroophthalmology. 2016; 39(6):281-284.

PMID: 27928370 PMC: 5123131. DOI: 10.3109/01658107.2015.1084333.

Neuro-ophthalmology and neuro-otology update.

Gold D, Zee D J Neurol. 2015; 262(12):2786-92.

PMID: 26122540 DOI: 10.1007/s00415-015-7825-1.

Asymmetric papilledema in idiopathic intracranial hypertension.

Bidot S, Bruce B, Saindane A, Newman N, Biousse V J Neuroophthalmol. 2014; 35(1):31-6.

PMID: 25494197 PMC: 4326590. DOI: 10.1097/WNO.0000000000000205.

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