Replication of British Rheumatoid Arthritis Susceptibility Loci in Two Unrelated Chinese Population Groups

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2013 Oct 2

PMID 24082910

Citations 2

Authors

Hua Li

Yonghe Hu

Tao Zhang

Yang Liu

Yantang Wang

Tai Yang

Minhui Li

Qiaoli Luo

Yu Cheng

Qiang Zou

Affiliations

Soon will be listed here.

Abstract

Previous genome-wide association study by WTCCC identified many susceptibility loci of common autoimmune diseases in British, including rheumatoid arthritis (RA). Because of the genetic heterogeneity of RA, it is necessary to replicate these susceptibility loci in other populations. Here, three SNPs with strong RA association signal in the British were analyzed in Han Chinese, and two SNPs (rs6457617 and rs11761231) were genotyped in the test cohort firstly. The rs6457617 was significantly associated with RA in the test cohort. The individuals bearing the homozygous genotype CC had 0.39-fold risk than these bearing the wild-type genotype TT (P = 0.004, OR 0.39, [95% CI 0.21-0.74]). And the protective effect of allele C was confirmed in another validation cohort with 1514 samples (P genotye CC/TT = 5.9 × 10(-10), OR 0.34, [95% CI 0.24-0.48]). The rs6457617 can be used as a tagSNP of HLA-DQA1∗03 which encoded MHC-II α chain. Since MHC restriction is important for primary T-cells in positive selection and negative selection stages, MHC protein polymorphisms may be implicated in shaping the T-cell repertoire, including the emergence of a T-cell clone involved in the inflammatory arthritis.

Citing Articles

Comparative study for haplotype block partitioning methods - Evidence from chromosome 6 of the North American Rheumatoid Arthritis Consortium (NARAC) dataset.

Saad M, Mabrouk M, Eldeib A, Shaker O PLoS One. 2019; 13(12):e0209603.

PMID: 30596705 PMC: 6312333. DOI: 10.1371/journal.pone.0209603.

Analysis of two susceptibility SNPs in HLA region and evidence of interaction between rs6457617 in HLA-DQB1 and HLA-DRB1*04 locus on Tunisian rheumatoid arthritis.

Achour Y, Ben Hamad M, Chaabane S, Rebai A, Marzouk S, Mahfoudh N J Genet. 2018; 96(6):911-918.

PMID: 29321349 DOI: 10.1007/s12041-017-0855-y.

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