Genetic Association with Response to Intravitreal Ranibizumab for Neovascular Age-related Macular Degeneration in the Han Chinese Population

Overview

Journal Ophthalmologica

Publisher Karger

Specialty Ophthalmology

Date 2013 Oct 2

PMID 24080590

Citations 7

Authors

Dongqing Yuan

Donglan Yuan

Xiaoyi Liu

Songtao Yuan

Ping Xie

Qinghuai Liu

Affiliations

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Abstract

Purpose: To investigate a possible association between gene variants and patient response to treatment with intravitreal ranibizumab for neovascular age-related macular degeneration (AMD).

Methods: Visual acuity score (VAS) was recorded at baseline and a subsequent visit at 6 months. Genotypes of 3 polymorphisms in known AMD susceptibility loci (rs1061170 in complement factor H (CFH), rs11200638 in HTRA1 and rs1413711 in VEGF) were determined. Central retinal thickness and maximum thickness of the lesion were also measured.

Results: A total of 168 neovascular AMD patients treated with intravitreal ranibizumab were included in our study. For HTRA1 rs11200638, mean VAS changes were 3.5, 9.4 and 10.6 letters for the AA, AG and GG genotypes, respectively (p = 0.022). In contrast, for CFH rs1061170 and VEGF rs1413711, mean VAS changes were not significant. However, there was no significant difference in the changes in central retinal thickness and maximum lesion thickness among the genotypes of the tested single-nucleotide polymorphisms.

Conclusions: HTRA1 gene polymorphism may influence patient response to treatment with intravitreal ranibizumab for neovascular AMD.

Citing Articles

An Updated Review of the Epigenetic Mechanism Underlying the Pathogenesis of Age-related Macular Degeneration.

Li X, He S, Zhao M Aging Dis. 2020; 11(5):1219-1234.

PMID: 33014534 PMC: 7505275. DOI: 10.14336/AD.2019.1126.

Genetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

Yoneyama S, Sakurada Y, Kikushima W, Sugiyama A, Matsubara M, Fukuda Y Sci Rep. 2020; 10(1):7188.

PMID: 32346038 PMC: 7189239. DOI: 10.1038/s41598-020-64301-z.

Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects.

Mohamad N, Ramachandran V, Mohd Isa H, Chan Y, Ngah N, Ching S Hum Genomics. 2019; 13(1):13.

PMID: 30795802 PMC: 6387522. DOI: 10.1186/s40246-019-0197-3.

Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration.

Lores-Motta L, de Jong E, den Hollander A Mol Diagn Ther. 2018; 22(3):315-343.

PMID: 29700787 PMC: 5954014. DOI: 10.1007/s40291-018-0332-1.

Analysis of the association between CFH Y402H polymorphism and response to intravitreal ranibizumab in patients with neovascular age-related macular degeneration (nAMD).

Mohamad N, Ramachandran V, Ismail P, Mohd Isa H, Chan Y, Ngah N Bosn J Basic Med Sci. 2018; 18(3):260-267.

PMID: 29579408 PMC: 6087554. DOI: 10.17305/bjbms.2018.2493.