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G1 Compartmentalization and Cell Fate Coordination

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2013 Oct 1
PMID 24074854
Citations 17
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Abstract

Pauklin and Vallier show that, whereas early G1 is permissive for TGF-β-dependent endoderm differentiation, cyclin D restricts the activity of Smad2/3 in late G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells. These findings provide insight into how signaling, the cell cycle, and lineage specification are coordinated.

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