Cholesterol and Copper Affect Learning and Memory in the Rabbit

Overview

Journal Int J Alzheimers Dis

Publisher Wiley

Date 2013 Sep 28

PMID 24073355

Citations 10

Authors

Bernard G Schreurs

Affiliations

Soon will be listed here.

Abstract

A rabbit model of Alzheimer's disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease including beta amyloid accumulation and learning and memory changes. Although we have shown that feeding 2% cholesterol and adding copper to the drinking water can retard learning, other studies have shown that feeding dietary cholesterol before learning can improve acquisition and feeding cholesterol after learning can degrade long-term memory. We explore the development of this model, the issues surrounding the role of copper, and the particular contributions of the late D. Larry Sparks.

Citing Articles

The Function of Transthyretin Complexes with Metallothionein in Alzheimer's Disease.

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Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper.

Taylor A, Tsuji J, Garry M, McArdle M, Goodfellow Jr W, Adams W Environ Manage. 2019; 65(1):131-159.

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The rabbit as a behavioral model system for magnetic resonance imaging.

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A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus.

Brooks S, Dykes A, Schreurs B J Alzheimers Dis. 2016; 56(1):185-196.

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Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model.

Liu Q, Koukiekolo R, Zhang D, Smith B, Ly D, Lei J Am J Neurodegener Dis. 2016; 5(1):74-84.

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