Association Between IL-4 -590C>T Polymorphism and Gastric Cancer Risk

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Sep 28

PMID 24072495

Citations 15

Authors

Zihan Sun

Yuling Cui

Xiaohong Jin

Jing Pei

Affiliations

Soon will be listed here.

Abstract

Published studies on the association between interleukin-4 (IL-4) -590C>T polymorphism and gastric cancer risk have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. All eligible studies of -590C>T polymorphism and gastric cancer risk were collected from the PubMed, the Cochrane Library, and the Embase electronic databases. Statistical analyses were performed by Review Manager 5.0 and Stata 11.0. When all groups were pooled, we did not detect a significant association of -590C>T polymorphism with gastric cancer risk. When stratifying for race, there was a significant association between -590C>T polymorphism and decreased gastric cancer risk under dominant model and allelic model in the subgroup of Caucasians. However, significant association was absent in Asians. Based on our meta-analysis, -590C>T polymorphism was associated with a lower gastric cancer risk under dominant model and allelic model in Caucasians. Nevertheless, we suggest that further studies should be made to confirm these findings.

Citing Articles

Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

Song X, Traub B, Shi J, Kornmann M Int J Mol Sci. 2021; 22(2).

PMID: 33450900 PMC: 7828336. DOI: 10.3390/ijms22020727.

Roles of IL-4 genetic polymorphisms and haplotypes in the risk of gastric cancer and their interaction with environmental factors.

Yun Y, Dong W, Chen C, Zhang H, Shi N, He M Int J Clin Exp Pathol. 2020; 10(8):8936-8943.

PMID: 31966763 PMC: 6965378.

Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis.

de Brito B, da Silva F, de Melo F World J Clin Oncol. 2018; 9(5):83-89.

PMID: 30254963 PMC: 6153128. DOI: 10.5306/wjco.v9.i5.83.

Association between four SNPs in IL-4 and the risk of gastric cancer in a Chinese population.

Wang Y, Li H, Wang X, Gao F, Yu L, Chen X Int J Mol Epidemiol Genet. 2017; 8(4):45-52.

PMID: 29034061 PMC: 5636916.

Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population.

Sampaio A, Balseiro S, Silva M, Alarcao A, dAguiar M, Ferreira T GE Port J Gastroenterol. 2017; 22(4):143-152.

PMID: 28868397 PMC: 5580160. DOI: 10.1016/j.jpge.2015.04.001.

References

Kim J, Kim J, Yoon H, Kang M, Kim J, Lee Y . Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer. Tumour Biol. 2012; 33(3):731-8. DOI: 10.1007/s13277-011-0267-1. View

Zhang H, Xu Y, Zhang Z, Liu R, Ma B . Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis. BMC Immunol. 2012; 13:14. PMC: 3337286. DOI: 10.1186/1471-2172-13-14. View

Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S . Thrombin activatable fibrinolysis inhibitor and thrombin-antithrombin-III-complex levels in patients with gastric cancer. Tumour Biol. 2012; 33(5):1519-25. DOI: 10.1007/s13277-012-0403-6. View

Pandith A, Siddiqi M . Burden of cancers in the valley of Kashmir: 5 year epidemiological study reveals a different scenario. Tumour Biol. 2012; 33(5):1629-37. DOI: 10.1007/s13277-012-0418-z. View

Zhang H, Qi C, Li L, Luo F, Xu Y . Clinical significance of NUCB2 mRNA expression in prostate cancer. J Exp Clin Cancer Res. 2013; 32(1):56. PMC: 3751731. DOI: 10.1186/1756-9966-32-56. View

Shacter E, Weitzman S . Chronic inflammation and cancer. Oncology (Williston Park). 2002; 16(2):217-26, 229; discussion 230-2. View

Smith A, Humphries S . Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev. 2008; 20(1):43-59. DOI: 10.1016/j.cytogfr.2008.11.006. View

Nakashima H, Miyake K, Inoue Y, Shimizu S, Akahoshi M, Tanaka Y . Association between IL-4 genotype and IL-4 production in the Japanese population. Genes Immun. 2002; 3(2):107-9. DOI: 10.1038/sj.gene.6363830. View

Zambon C, Basso D, Marchet A, Fasolo M, Stranges A, Schiavon S . IL-4 -588C>T polymorphism and IL-4 receptor alpha [Ex5+14A>G; Ex11+828A>G] haplotype concur in selecting H. pylori cagA subtype infections. Clin Chim Acta. 2008; 389(1-2):139-45. DOI: 10.1016/j.cca.2007.12.008. View

10.

Garcia-Gonzalez M, Lanas A, Quintero E, Nicolas D, Parra-Blanco A, Strunk M . Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007; 102(9):1878-92. DOI: 10.1111/j.1572-0241.2007.01423.x. View

11.

Vidal-Vanaclocha F . Inflammation in the molecular pathogenesis of cancer and atherosclerosis. Reumatol Clin. 2011; 5 Suppl 1:40-3. DOI: 10.1016/j.reuma.2008.12.008. View

12.

Masuda G, Tokunaga A, Shirakawa T, Togashi A, Kiyama T, Kato S . Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years. Gastric Cancer. 2007; 10(2):98-103. DOI: 10.1007/s10120-007-0414-y. View

13.

Mosser D, Zhang X . Interleukin-10: new perspectives on an old cytokine. Immunol Rev. 2009; 226:205-18. PMC: 2724982. DOI: 10.1111/j.1600-065X.2008.00706.x. View

14.

Ko K, Park S, Cho L, Gwack J, Yang J, Shin A . Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk. J Nutr. 2009; 139(5):1008-12. DOI: 10.3945/jn.108.101865. View

15.

Kushi L, Byers T, Doyle C, Bandera E, McCullough M, McTiernan A . American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2006; 56(5):254-81. DOI: 10.3322/canjclin.56.5.254. View

16.

Zhang H, Li L, Xu Y . CYP1B1 polymorphisms and susceptibility to prostate cancer: a meta-analysis. PLoS One. 2013; 8(7):e68634. PMC: 3701676. DOI: 10.1371/journal.pone.0068634. View

17.

Serefoglou Z, Yapijakis C, Nkenke E, Vairaktaris E . Genetic association of cytokine DNA polymorphisms with head and neck cancer. Oral Oncol. 2008; 44(12):1093-9. DOI: 10.1016/j.oraloncology.2008.02.012. View

18.

Rosenwasser L, Klemm D, Dresback J, Inamura H, Mascali J, Klinnert M . Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy. 1995; 25 Suppl 2:74-8; discussion 95-6. DOI: 10.1111/j.1365-2222.1995.tb00428.x. View

19.

Baniyash M . Chronic inflammation, immunosuppression and cancer: new insights and outlook. Semin Cancer Biol. 2006; 16(1):80-8. DOI: 10.1016/j.semcancer.2005.12.002. View

20.

Zhang H, Xu Y, Zhang Z, Li L . Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer. Genet Mol Res. 2012; 11(2):1642-50. DOI: 10.4238/2012.June.15.13. View