SOCS, Inflammation, and Cancer

Overview

Journal JAKSTAT

Date 2013 Sep 27

PMID 24069550

Citations 120

Authors

Kyoko Inagaki-Ohara

Taisuke Kondo

Minako Ito

Akihiko Yoshimura

Affiliations

Soon will be listed here.

Abstract

Signal transduction pathways elicited by cytokines and hormones have been shown to regulate distinct stages of development. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of cytokine signaling mediated by the JAK-STAT signaling pathway. In particular, SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers. Abnormal expression of SOCS1 and SOCS3 in cancer cells has been reported in human carcinoma associated with dysregulation of signals from cytokine receptors, Toll-like receptors (TLRs), and hormone receptors, resulting in malignancies. In this review, we focus on the role of SOCS1 and SOCS3 in cancer development. In addition, the potential of SOCS as a therapeutic target and diagnostic aid will be discussed.

Citing Articles

SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma.

Marroquin-Mucino M, Benito-Lopez J, Perez-Medina M, Aguilar-Cazares D, Galicia-Velasco M, Chavez-Dominguez R Int J Mol Sci. 2024; 25(22).

PMID: 39596207 PMC: 11595078. DOI: 10.3390/ijms252212141.

Deciphering the role of LncRNA in alcoholic liver disease: Mechanisms and therapeutic potential.

Zhang L, Wang R, Nan Y, Kong L Medicine (Baltimore). 2024; 103(45):e40378.

PMID: 39533619 PMC: 11557020. DOI: 10.1097/MD.0000000000040378.

SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation.

Morelli M, Madonna S, Albanesi C Front Immunol. 2024; 15:1393799.

PMID: 38975347 PMC: 11224294. DOI: 10.3389/fimmu.2024.1393799.

SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity.

Ilangumaran S, Gui Y, Shukla A, Ramanathan S Front Immunol. 2024; 15:1362224.

PMID: 38415248 PMC: 10897024. DOI: 10.3389/fimmu.2024.1362224.

The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma.

Shukla A, Khan M, Cayarga A, Namvarpour M, Chowdhury M, Levesque D Cancers (Basel). 2024; 16(2).

PMID: 38254783 PMC: 10814246. DOI: 10.3390/cancers16020292.

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