Regulatory T Cells Control Immune Responses Through Their Non-Redundant Tissue Specific Features

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Sep 27

PMID 24069022

Citations 20

Authors

Sari Lehtimaki

Riitta Lahesmaa

Affiliations

Soon will be listed here.

Abstract

Regulatory T cells (Treg) are needed in the control of immune responses and to maintain immune homeostasis. Of this subtype of regulatory lymphocytes, the most potent are Foxp3 expressing CD4+ T cells, which can be roughly divided into two main groups; natural Treg cells (nTreg), developing in the thymus, and induced or adaptive Treg cells (iTreg), developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, non-redundant roles in the immune system, with nTreg cells mainly maintaining tolerance toward self-structures, and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body.

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