Genomic Analysis of HAdV-B14 Isolate from the Outbreak of Febrile Respiratory Infection in China

Overview

Journal Genomics

Specialty Genetics

Date 2013 Sep 24

PMID 24055951

Citations 10

Authors

Zhiqiang Mi

Azeem Mehmood Butt

Xiaoping An

Tao Jiang

Wei Liu

Chengfeng Qin

Wu-Chun Cao

Yigang Tong

Affiliations

Soon will be listed here.

Abstract

Human adenovirus type 14 (HAdV-B14) was first reported in 1955 from the Netherlands and since then had been associated with outbreaks of febrile respiratory illness (FRI). In China, sporadic HAdV-B14 infections were first identified in 2010, in Guangzhou and Beijing. In 2012, an outbreak of FRI occurred in Beijing and the etiological agent was determined to be HAdV-B14. We present a complete HAdV-B14 genome sequence isolated from this recent FRI outbreak. Virus in 30 throat swab samples was detected using polymerase chain reaction assays, and confirmed by sequencing of the fiber, hexon and penton genes. Comparative genomics and phylogenetic analysis showed that the newly isolated HAdV-B14 (HAdV-B14 CHN) shared highest sequence homology with a 2006 isolate from the United States and clustered closely with other HAdV-B14 strains. It is expected that data from the present study will help in devising better protocols for virus surveillance, and in developing preventative measures.

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References

Akusjarvi G, Mathews M, Andersson P, Vennstrom B, Pettersson U . Structure of genes for virus-associated RNAI and RNAII of adenovirus type 2. Proc Natl Acad Sci U S A. 1980; 77(5):2424-8. PMC: 349411. DOI: 10.1073/pnas.77.5.2424. View

Berk A . Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene. 2005; 24(52):7673-85. DOI: 10.1038/sj.onc.1209040. View

Horwitz M . Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J Gene Med. 2004; 6 Suppl 1:S172-83. DOI: 10.1002/jgm.495. View

Purkayastha A, Su J, Carlisle S, Tibbetts C, Seto D . Genomic and bioinformatics analysis of HAdV-7, a human adenovirus of species B1 that causes acute respiratory disease: implications for vector development in human gene therapy. Virology. 2005; 332(1):114-29. DOI: 10.1016/j.virol.2004.10.041. View

Finnen R, Biddle J, Flint J . Truncation of the human adenovirus type 5 L4 33-kDa protein: evidence for an essential role of the carboxy-terminus in the viral infectious cycle. Virology. 2001; 289(2):388-99. DOI: 10.1006/viro.2001.1130. View

Mei Y, Skog J, Lindman K, Wadell G . Comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species B, and the commonly used human adenovirus 5 vector, a member of species C. J Gen Virol. 2003; 84(Pt 8):2061-2071. DOI: 10.1099/vir.0.19178-0. View

Ma Y, Mathews M . Structure, function, and evolution of adenovirus-associated RNA: a phylogenetic approach. J Virol. 1996; 70(8):5083-99. PMC: 190463. DOI: 10.1128/JVI.70.8.5083-5099.1996. View

Green N, WRIGLEY N, Russell W, Martin S, McLachlan A . Evidence for a repeating cross-beta sheet structure in the adenovirus fibre. EMBO J. 1983; 2(8):1357-65. PMC: 555283. DOI: 10.1002/j.1460-2075.1983.tb01592.x. View

BOULANGER P, Lemay P, Blair G, Russell W . Characterization of adenovirus protein IX. J Gen Virol. 1979; 44(3):783-800. DOI: 10.1099/0022-1317-44-3-783. View

10.

Chatterjee P, Vayda M, Flint S . Identification of proteins and protein domains that contact DNA within adenovirus nucleoprotein cores by ultraviolet light crosslinking of oligonucleotides 32P-labelled in vivo. J Mol Biol. 1986; 188(1):23-37. DOI: 10.1016/0022-2836(86)90477-8. View

11.

Zhang Q, Seto D, Zhao S, Zhu L, Zhao W, Wan C . Genome sequence of the first human adenovirus type 14 isolated in China. J Virol. 2012; 86(12):7019-20. PMC: 3393531. DOI: 10.1128/JVI.00814-12. View

12.

Cooper R, Hallett R, Tullo A, Klapper P . The epidemiology of adenovirus infections in Greater Manchester, UK 1982-96. Epidemiol Infect. 2000; 125(2):333-45. PMC: 2869606. DOI: 10.1017/s0950268899004550. View

13.

Wickham T, Mathias P, Cheresh D, Nemerow G . Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell. 1993; 73(2):309-19. DOI: 10.1016/0092-8674(93)90231-e. View

14.

Dan A, Elo P, Harrach B, Zadori Z, Benko M . Four new inverted terminal repeat sequences from bovine adenoviruses reveal striking differences in the length and content of the ITRs. Virus Genes. 2001; 22(2):175-9. DOI: 10.1023/a:1008125324346. View

15.

Leppard K . E4 gene function in adenovirus, adenovirus vector and adeno-associated virus infections. J Gen Virol. 1997; 78 ( Pt 9):2131-8. DOI: 10.1099/0022-1317-78-9-2131. View

16.

Houng H, Gong H, Kajon A, Jones M, Kuschner R, Lyons A . Genome sequences of human adenovirus 14 isolates from mild respiratory cases and a fatal pneumonia, isolated during 2006-2007 epidemics in North America. Respir Res. 2010; 11:116. PMC: 2933684. DOI: 10.1186/1465-9921-11-116. View

17.

Gu L, Liu Z, Li X, Qu J, Guan W, Liu Y . Severe community-acquired pneumonia caused by adenovirus type 11 in immunocompetent adults in Beijing. J Clin Virol. 2012; 54(4):295-301. PMC: 7185447. DOI: 10.1016/j.jcv.2012.04.018. View

18.

Liu G, Babiss L, Volkert F, Young C, Ginsberg H . A thermolabile mutant of adenovirus 5 resulting from a substitution mutation in the protein VIII gene. J Virol. 1985; 53(3):920-5. PMC: 254727. DOI: 10.1128/JVI.53.3.920-925.1985. View

19.

Mul Y, Verrijzer C, van der Vliet P . Transcription factors NFI and NFIII/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication. J Virol. 1990; 64(11):5510-8. PMC: 248603. DOI: 10.1128/JVI.64.11.5510-5518.1990. View

20.

Huang G, Yu D, Zhu Z, Zhao H, Wang P, Gray G . Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China. Influenza Other Respir Viruses. 2013; 7(6):1048-54. PMC: 3933759. DOI: 10.1111/irv.12118. View