Identification of MHC Class I Sequences in Four Species of Macaca of China

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2013 Sep 19

PMID 24045838

Citations 3

Authors

Xiang Yan

Aixue Li

Lin Zeng

Yuhua Cao

Jianbin He

Longbao Lv

Lihua Sui

Huahu Ye

Junwen Fan

Xiaoxia Cui

Zhaozeng Sun

Affiliations

Soon will be listed here.

Abstract

Tibetan macaques (Macaca thibetana), stump-tailed macaques (M. arctoides), Assamese macaques (M. assamensis), and northern pig-tailed macaques (M. leonina) are four major species of Macaca in China. In order to effectively use these species in biomedical research, thorough investigations of their MHC immunogenetics are required. In this study, we identified MHC class I sequences using cDNA cloning and sequencing on a cohort of six M. thibetana, three M. arctoides, three M. assamensis, and three M. leonina derived from Sichuan and Yunnan provinces of China. Eighty new alleles were identified, including 26 MHC-A alleles, 46 MHC-B alleles, and 8 MHC-I alleles. Among them, Math-A1*126:01, Math-B*190:01, Math-B*191:01, Math-B*192:01, Maar-A1*127:01, Maar-A1*129:01, and Maas-A1*128:01 represent lineages that had not been reported earlier in Macaca. Phylogenetic analyses show that no obvious separation of lineages among these species of Macaca. This study provides important information about the MHC immunogenetics for the four major species of Chinese macaques and adds value to these species as model organisms in biomedical research.

Citing Articles

MHC class I allele diversity in cynomolgus macaques of Vietnamese origin.

Huang S, Huang X, Li S, Zhu M, Zhuo M PeerJ. 2019; 7:e7941.

PMID: 31720104 PMC: 6836755. DOI: 10.7717/peerj.7941.

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.

de Groot N, Otting N, Maccari G, Robinson J, Hammond J, Blancher A Immunogenetics. 2019; 72(1-2):25-36.

PMID: 31624862 DOI: 10.1007/s00251-019-01132-x.

Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina).

Lian X, Zhang X, Dai Z, Zheng Y Immunogenetics. 2016; 68(4):261-74.

PMID: 26782049 DOI: 10.1007/s00251-015-0897-3.

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