Aberrant Expression of SLex and SLea As Candidate Prognostic Factors for Feline Mammary Gland Tumour

Overview

Journal J Feline Med Surg

Specialty Veterinary Medicine

Date 2013 Sep 18

PMID 24043722

Citations 1

Authors

Saori Yoshida

Kota Yoshida

Tassanee Jaroensong

Soo-Jung Lee

Ayako Kamida

Kohei Saeki

Naoki Fujita

Ryohei Nishimura

Nobuo Sasaki

Takayuki Nakagawa

Affiliations

Soon will be listed here.

Abstract

Expression of the carbohydrate antigens sialyl Lewis x (sLe(x)) and a (sLe(a)) was evaluated in feline mammary gland tumours (FMGT). Immunohistochemical analysis of tissues from 21 FMGT patients and 11 healthy cats revealed significantly higher sLe(x) and sLe(a) antigen expression in adenocarcinoma tissues compared with that of normal mammary tissues (P <0.01). Serum concentration of sLe(x) was evaluated using an enzyme-linked immunosorbent assay and was significantly higher in the 11 FMGT patients (4.71 ± 10.1 U/ml) than the 22 patients with other disease (2.69 ± 1.59 U/ml) (P = 0.03) and the 22 healthy cats (3.71 ± 1.10 U/ml), although the latter difference was not significant. Although the number of cases examined in this study was small, our findings suggest that aberrant expression of sLe antigens may be induced by tumourigenesis in FMGT and that sLe antigens are potential prognostic tumour markers for FMGT.

Citing Articles

sLe expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator.

Song Y, Sun H, Wu K, Lyu J, Zhang J, Gu F Cancer Biol Med. 2021; .

PMID: 33893728 PMC: 8185870. DOI: 10.20892/j.issn.2095-3941.2020.0422.

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